Table of Contents

Section 1. Introduction. P.S. Sachdev, The Ageing Brain. G.A. Broe, Population Ageing, Human Lifespan and Neurodegenerative Disorders: A Fifth Epidemiologic Transition. Section 2. Characteristics of the Ageing Brain. J.J. Kril, Structural Changes in the Ageing Human Brain. J.C.L. Looi, P.S. Sachdev, Structural Neuroimaging of the Ageing Brain. S.R. Lord, R. St George, Neurophysiological, Sensory and Motor Changes with Ageing. H. Christensen, R. Kumar, Cognitive Changes and the Ageing Brain. J.N. Trollor, P.S. Sachdev, Ageing of the Human Brain as Studied by Functional Neuroimaging. G.A. Smythe, Neuroendocrine Aspects of Brain Ageing. V.K. Srikanth, G.A. Donman, Cerebrovascular System and the Ageing Brain. Section 3. Factors Influencing Brain Ageing. J.B.J. Kwok, P.R. Schofield, The Molecular Basis of Alzheimer’s Disease and Frontotemporal Dementia. J. de Haan, R.C. Iannello, P.J. Crack, P. Hertzog, I. Kola, Oxidative and Free Radical Mechanisms in Brain Ageing. J. Bryan, The Role of Nutritional Factors in Cognitive Ageing. P.W. Schofield, The Brain Reserve Hypothesis. Section 4. Clinical Interface. C. Brayne, Will We All Dement if We Live Long Enough? G.W. Small, Detecting Alzheimer’s Disease at the Pre-Symptomatic Stage. J.G.L. Morris, M.A. Hely, G.M. Halliday, Parkinsonism and Ageing. J. Snowdon, Age Variation in the Prevalence of Depression: Are Study Findings Meaningful? P.S. Sachdev, Vascular Dementia. P.S. Sachdev, Conclusion.