Table of Contents

1 INTRODUCTION TO THE IMMUNE SYSTEM,

Nomenclature, General Properties, and Components

2 INNATE IMMUNITY,

The Early Defense Against Infections

3 ANTIGEN CAPTURE AND PRESENTATION TO LYMPHOCYTES,

What Lymphocytes See

4 ANTIGEN RECOGNITION IN THE ADAPTIVE IMMUNE SYSTEM,

Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires

5 T CELL-MEDIATED IMMUNITY,

Activation of T Lymphocytes by Cell-Associated Antigens

6 EFFECTOR MECHANISMS OF T CELL-MEDIATED IMMUNITY,

Functions of T Cells in Host Defense

7 HUMORAL IMMUNE RESPONSES,

Activation of B Lymphocytes and Production of Antibodies

8 EFFECTOR MECHANISMS OF HUMORAL IMMUNITY,

Elimination of Extracellular Microbes and Toxins

9 IMMUNOLOGICAL TOLERANCE AND AUTOIMMUNITY,

Self-Nonself Discrimination in the Immune System and Its Failure

10 IMMUNE RESPONSES AGAINST TUMORS AND TRANSPLANTS,

Immunity to Noninfectious Transformed and Foreign Cells

11 HYPERSENSITIVITY,

Disorders Caused by Immune Responses

12 CONGENITAL AND ACQUIRED IMMUNODEFICIENCIES,

Diseases Caused by Defective Immunity

SELECTED READINGS,

APPENDIX I,

Glossary

APPENDIX II,

Cytokines

APPENDIX III,

Principal Features of Selected CD Molecules

APPENDIX IV,

Clinical Cases

INDEX,

About the Author

Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California