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Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology

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Encyclopedia of Industrial Biotechnology

Bioprocess, Bioseparation, and Cell Technology

By Michael C. Flickinger (Edited by)

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Format: Hardback, 5248 pages
Other Information: Illustrations
Published In: United Kingdom, 27 April 2010
The Encyclopedia of Industrial Biotechnology combinesWiley s acclaimed Encyclopedia of BioprocessTechnology and the Encyclopedia of Cell Technology inorder to create a single resource and gateway to the many areas ofindustrial biotechnology for students, researchers, andtechnologists. In addition to revising and updating existingarticles, the new Encyclopedia of Industrial Biotechnologyhas been greatly expanded to cover important areas ofpharmaceutical and biologics bioprocess technology, including: * Production of vaccines * Biopharmaceuticals and methods for manufacturingbiomaterials * Biofabrication for the production of microfluidics * Tissue engineering * Biosensors * Bioelectronics * Bioarrays * Bio-nanotechnology


The Encyclopedia of Industrial Biotechnology waspublished in order to help readers make sense of the vast amountsof information that have been published around the world across abroad array of ournals, books, and websites. With its comprehensivecoverage, Encyclopedia of Industrial Biotechnology is theideal starting point for research projects involving any aspect ofindustrial biological processes, including fermentation,biocatalysis, bioseparation, and biofabrication.

Table of Contents

1,2 and 1,3 Propanediol, Microbial Production Methods ( DehuaLiu).

Acclimatization of plantlets from in vitro to the ambientenvironment (John Preece). Acetic acid bacteria and their biotechnological applications(Luciana De Vero). Acrylamide, microbial production by nitrile hydratase (YuguoZheng). Adsorption in Simulated Moving Beds (C.C. Santana). Adsorption, proteins with synthetic materials (JosephMcGuire). Adventitious Organogenesis (Geert-Jan de Klerk). Aeration, Mixing and Hydrodynamics in Bioreactors (JeffreyChalmers). Affinity chromatography Fractionated and DNA-engineeredplasma proteins (Thierry Burnouf). Affinity Fusions, gene expression (SusanneGraslund). Aflatoxin (Jiujang Yu). Agricultural Biotechnology, Ethics, Food Safety, Risk, andIndividual Consent (Paul Thompson). Agricultural Biotechnology, Socioeconomic Effects, and the FourthCriterion (William Lacy). Aldehyde Reductase (Sayaku Shimizu). Algal Hydrogen Production (Maria L. Ghirardi). Amino Acid Production, L-Lysine (Hisashi Yasueda). Anaerobes (Larry E. Erickson). Animal Cell Culture Media (Ashraf Amanullah). Animal Cell Culture, Physiochemical Effects of Osmolality andTemperature (Shyamsundar Subramanian). Animal Cell Types, B Cell Lineage (K. Walker). Animal Cell Types, Hybridoma Cells (Burkhard Micheel). Animal Cell Types, Monocyte, Macrophage Lineage (K.Walker). Antibiotics Biosynthesis (Tilmann Weber). Antibiotics, Polyketide (Yi Tang). Antibody Engineering (Sherie Morrison). Antibody Manufacture, Disposable Systems (RegineEibl-Schindler). Antibody Production, Human, Recombinant (StefanDubel). Antibody, purification (Michiel Ultee). Anticancer Compounds: Development, structural modifications andtherapeutic applications (Gabriel Padilla). Apoptosis (Mohamed Al-Rubeai). Aptasensors (Alessandra Bini). Aseptic Techniques in Cell Culture (John Davis).

Bacillus megaterium and other Bacilli, Industrial Applications(Dieter Jahn). Baculovirus Expression Systems (Linda King). Baculovirus kinetics in insect cell culture (LarsNielsen). Basidiomycetous yeasts for production of carotenoids (PietroBuzzini). Beer Brewing, Applications of Metabolic Engineering (LisbethOlsson). Biocatalysis, cofactor regeneration (Jian-He Xu). Biocatalytic Membrane Reactors (Enrico Drioli). Biocatalytic Synthesis of ss-lactam Antibiotics (AndreasBommarius). Biocers, Industrial Applications (Thibaud Coradin). Bio-electronics (James Fleming). Bioenergetics of microbial growth (RobbertKleerebezem). Biofilters (Mario Zilli). Biofuel Cells, Enzyme Catalysis of Oils (Shelley D.Minteer). Biofuel Cells, Performance Characterization (K.Watanabe). Biominiaturization of Bioreactors (Michael Hanson). Bionanofabrication (Carl Batt). Biopharmaceutics, Pharmacokinetics and Pharmacodynamics of ProteinTherapeutics (Bernd Meibohm). Biophotoreceptor Arrays (George Knopf). Biopolyester particles: preparation and applications (BerndRehm). Bio-printing (Douglas Chrisey). Bioprinting Inkjet deposition (Brian Derby). Bioprocess Design, Computer-Aided (Demetri Petrides). Bioreactor Scale-Down (Octavio Ramirez). Bioreactor Scale-Up (Octavio Ramirez). Bioreactors, Air-Lift Reactors (Jose Merchuk). Bioreactors, Fluidized-Bed (Winfried Storhas). Bioreactors, Mist (P. Weathers). Bioreactors, Perfusion (Wei Wen Su). Bioreactors, Stirred Tank for Plant Cells Culture (PaulineDoran). Bioreduction (Marie Gorwa-Grauslund). Bioremediation (Owen Ward). Biosensors, Color-Sensitive (Lasse Lensu). Biosensors, Environmental (Amarjeet S. Bassi). Biosensors, Foodboure Pathogen Detection (Arun K.Bhunia). Biosensors, Toxicity Monitoring (Silvana Andreescu). Bioseparation, Magnetic Particle Adsorbents (UrsPeuker). Biosorption, metals (Bohumil Volesky). Biosynthesis of Microbial Primary Metabolites (ArnoldDemain). Biotransformation of Synthetic Fibers (ArturCavaco-Paulo). Biotransformation, Process Optimization, Kinetics and EngineeringAspects (Andreas Liese). Bryophyte In Vitro Cultures, Secondary Products ( HansBecker).

Carbonyl Reductase (Hiroaki Yamamoto). Carotenoids, Microbial Processes (ClaudiaSchmidt-Dannert). Cell Culture, Bioreactors, Commercial Production (Jian-JiangZhong). Cell Cycle (Mohamed Al-Rubeai). Cell Cycle in Suspension Cultured Plant Cells (MarkFowler). Cell Cycle Synchronization (Mohamed Al-Rubeai). Cell Detachment (Otto Merten). Cell Differentiation, Animal (Nancy Parenteau). Cell Disruption and Lysis (F. A. P. Garcia). Cell Disruption, Microbial, Micromechanical Properties (ArnoKwade). Cell Growth and Protein Expression Kinetics (DhinakarKompala). Cell Immobilization, Engineering Aspects (RonnieWillaert). Cell Products, Antibodies (John Birch). Cell Separation, centrifugation (Hans Axelsson). Cell Separation, flocculation (Eduardo Soares). Cell-Surface Receptors: Structure, Activation, and Signaling(Kristina Thiel). Central Metabolism Enhancement using Defective F1-ATPase(Atsushi Yokota). Chinese hamster ovary cells in recombinant protein production(David Hacker). Chiral Alcohols by Enzymatic Preparation (BirtheBorup). Chromatographic purification of virus particles (PeterGagnon). Chromatography, hydrophobic interaction (HIC) (PerKarsnas). Chromatography, Industrial Scale, Validation (SandyWeinberg). Chromatography, radial flow (Tingyue Gu). Citric Acid Processes (Peter Christian Kubicek). Cleaning and Sanitization in Downstream Processing (DarcyBirse). Clean-In-Place, Piping Systems (Philip Bremer). Closed Systems in BioProcessing (Jeffrey Odum). Clostridia (Peter Durre). Conifers, Culture and Genetic Engineering (Jan Bonga). Contamination Detection and Elimination in Plant Cell Culture(A. Cassells). Crabtree Effect (Jacques Thierie). Crystallization, proteins, kinetics (Gianluca DiProfio). Culture Collections and Biological Resource Centres (BRCs)(David Smith). Cyclotides (Heike Dornenburg).

D-Aminopeptidase and Alkaline D-Peptidase (YasuhisaAsano). Database Tools for Microbial Biocatalysis (LawrenceWackett). Dehydrogenase (Antoni Sanchez). Dehydrogenases, Electrochemical Co-Factor Regeneration (PetraKornberger). dihydroxyphenylalanine (4), produced by microorganisms (HidehikoKumagai). Drying (Arun Mujumdar).

Edible Oils, Microbial Modification Processes (ChingHou). Energy Metabolism, microbial and animal cells (MichaelButler). Enzymatic C-C Bond Formation, Asymmetric (AndreasLiese). Enzymatic oligosaccharide synthesis (Klaus Buchholz). Enzymatic Synthesis of Chiral Intermediates For Developmentof Drugs (Ramesh N. Patel). Enzymatic transglycosylation (Antonio Trincone). Enzyme Immobilization, Biocatalyst Featured with NanoscaleStructure (Guanghui Ma). Enzyme-catalyzed reactions in ionic liquids (RomasKazlauskas). Enzyme-catalyzed synthesis of unnatural or modified nucleosides(Josep-Vicent Sinisterra). Enzymes, D-Amino Acid Oxidases (M.S. Pilone). Enzymes, Detergent (Karl-Heinz Maurer). Enzymes, Directed Evolution (Manfred Reetz). Enzymes, Ketoreductases (Harald Groger). Erythromycins (Wolfgang Minas). Ethanol, Fuel, Production by Yeasts (William MichaelIngledew). Ethical Issues in Animal and Plant Cell Technology (RaymondSpier). Expanded Bed Chromatography, Surface Energetics of BiomassDeposition (M. Fernandez Lahore). Extremely Thermophilic Enzymes (Robert Kelly). Extremely Thermophilic Microorganisms (Robert Kelly).

Flow Cytometry (Susann Muller). Flow Injection Analysis (FIA) (Elo Harald Hansen). Fluorescence Sensors for Bioprocess Monitoring (ThomasScheper). Flux Analysis of Mammalian Cell Culture (DirkMartens). Foam formation and control in bioreactors (J.P.Lecomte). Freeze Drying, pharmaceuticals (Jinsong Liu). Freezing, Biopharmaceutical Products (Phillippe Lam). Fungal metabolic engineering for cephalosporins production(Jose-Luis Barredo).

Gas hold-up in bioreactors (Christian Sieblist). Gene Expression, Human Cells (Marco Cacciuttolo). Glycochips (Juergen Seibel). Glycosylation (Michael Butler). Glyoxylate Bypass, Regulation (David LaPorte). Good Manufacturing Practice (GMP) and Good Industrial Large ScalePractice (GLSP) (Beth Junker).

Halophiles, Industrial Applications (PriyaDasSarma). Haploid Plant Production: Pollen/Anther/Ovule Culture (RichardVeilleux). Herbicide Resistant Plants (David Songstad). High-Throughput Technologies in Bioprocess Development (TrentCarrier). History of Animal Cell Technology (Raymond Spier). History of Biotechnology (Klaus Buchholz). Immobilization of Proteins and Enzymes, Mesoporous Supports(Martin Hartmann).

Immobilized Cells (Viktor Nedovic). Immobilized Enzymes (Jose Guisan). Immuno Flow Injection Analysis in Bioprocess Control (Jong IlRhee). Impeller Selection for Animal Cell Culture (A.W.Nienow). Industrial Biotransformation (Roland Wohlgemuth). Inoculum Expansion Methods for Recombinant Mammalian Cell Lines(Alahari Arunakumari). Insect Cells and Larvae, Gene Expression Systems (SomeetNarang).

Kinetics, enzymes (Athel Cornish-Bowden). Kinetics, Microbial Growth (Nicolai Panikov).

Laccase (Harald Claus). Lactonohydrolase (Sayaku Shimizu). L-aspartic acid (Hideaki Yukawa). Lipases (S.S. Kanwar). Lipases, Applications in Synthesis of Chiral Compounds and inOrganic Solvents (Uwe Bornscheuer). Lipopolysaccharide, LPS removal, depyrogenation (PerolaMagalhaes). L-isoleucine (Hideaki Yukawa). Luminescence (Cees Ronda).

Malic Acid, Production by Fumarase (Yonghong Hu). Mammalian Cell Bioreactors (Wei-Shou Hu). Manufacturing Scale Protein Chromatography (JosephBertolini). Mass Transfer (Yusuf Chisti). Measurement of Cell Viability (Ning Wei). Membrane Chromatography (Jorg Thommes). Membrane-Surface Liquid Culture (Kazuhiro Nakanishi). Methanotrophs (J. Colin Murrell). Methylotrophs, Industrial Applications (David Leak). Microalgae, mass culture methods (E. Molina Grima). Microbial Metabolite Export (Lothar Eggeling). Microbial production of rhamnolipid biosurfactants (RudolfHausmann). Microbiological Induced Corrosion and Inhibition (PatriziaPerego). Microcarrier culture (Susan Sharfstein). Micropropagation of Plants (Arie Altman). Mixed Culture (Suteaki Shioya). Modeling the flow distribution in large scale chromatographycolumns (Zhiwu Fang). Monoclonal Antibodies, Human Engineered (ManuelPenichet). Monoclonal Antibody Production, Cell Lines (DavidRobinson). Monocot Cell Culture (Richard Brettell). Monooxygenases, Baeyer-Villiger Applications in Organic Synthesis(Uwe Bornscheuer). Mycoplasma Contamination Of Cell Cultures (HansDrexler).

Nanomaterials Incorporated Bioelectronics (ChenzhongLi). Neural Stem Cells, Bioprocess Engineering (Leo Behie).

Off-Line Analysis in Animal Cell Culture (HeinoBuntemeyer). Oils, Microbial Production (Sayaku Shimizu). Old Yellow Enzyme' family and Enoate Reductases (AndreasBommarius). Optically Active Secondary Alcohols, Microbial Production byStereospecific Conversion (Keiko Yamada-Onodera). Organosilicon compounds (Takuo Kawamoto). Osmolarity Effects on Chinese Hamster Ovary Cell Culture (GyunMin Lee). Oxidation of alkenes by bacterial monooxygenases (ThomasSmith). Oxygen Transfer Rate Determination: Chemical, Physical andBiological Methods (Felix Garcia-Ochoa).

Pantothenic Acid and Related Compounds (SayakuShimizu). Peptides (Hans von Dohren). Phenylalanine Dehydrogenase (Yasuhisa Asano). Photobioreactors (Mario Tredici). Pichia, optimization of protein expression. (KotiSreekrishna). Pilot Plants, Design and Operation (Beth Junker). Plant Cell Culture, Laboratory Techniques (MarkFowler). Plant cell culture, secondary product accumulation (Jian-JiangZhong). Plant Cell Cultures, Photosynthetic (J. Widholm). Plasmid DNA Replication (Marcelo Tolmasky). Plasmid Purification, Therapeutic (Joao Marcos). Pluronic Polyols, cell protection (David Murhammer). Polyhydroxyalkanoates (Guoqiang Chen). Polysiloxanes, Biocatalytic Functionalization (MartinBertau). Porous Media, Applications in Biotechnology (ManuelMota). Process Monitoring (Anthony Turner). Protein aggregation and precipitation, measurement and control(Catherine Schein). Protein Glycosylation (Susan Brooks). Protein Processing, Endocytosis and Intracellular Sorting of GrowthFactors (Alexander Sorkin). Protein Purification, Large Scale, Using Self-Cleaving AggregationTags (David W. Wood). Protein synthesis and secretion from animal cells (RandalKaufman). Protein Ultrafiltration (Andrew L. Zydney). Proteins, Thermal Unfolding (Li Shi). Proteolytic Cleavage, Reaction Mechanisms (ThomasGraycar). Pseudomonas applications (Bernd Rehm). Pullulan, microbial production methods (Jules Thibault).

Quality by Design (QbD), Biotechnical Products (KurtBrorson).

Regulatory Requirements for Human Biopharmaceuticals, EuropeanCommunity (Gary Walsh). Reverse Micelles, enzymes (Haris Stamatis). Rheology of Filamentous Microorganisms, Submerged Culture (M.Papagianni). Rheology, flow behavior of fermentation fluids (ColinThomas).

Sampling and sample handling for process control (BoMattiasson). Scale-Up, Stirred Tank Reactors (A.W. Nienow). Secretion of Heterologous Proteins, Gram-Positive Bacteria,Lactococcus lactis (P. Langella). Shear Sensitivity (Yusuf Chisti). Single-Use (SU) Systems (Robert Maigetter). S-layers, Nanobiotechnological Applications (UweSleytr). Smart Biomaterials and Biosensors: Intelligent Properties ofBiomolecules and Cells in Hybrid Devices (KennethMarx). Solid Substrate Fermentation, Automation (RicardoPerez-Correa). Solid Substrate Fermentations, enzyme production, food enrichment(Yusuf Chisti). Soluble protein expression in bacteria (CatherineSchein). Solute Transport, Microbial (Robert Marquis). Spectral data comparability - acceptance criteria definition bystatistical analysis (Horst Bierau). Sterilization and Decontamination (Peter Roberts). Steroid Bioconversion (Pedro Fernandes). Suspension Culture, animal cells (John Birch).

Tea Bioactives (Ashim Mullick). Temperature Dependent Molecular Adaptations in Microbial Proteins(M. Gromiha). Thermostable Proteins: Structural Factors, Features and Engineering(Young Je Yoo). Transcription, Translation, and the Control of Gene Expression inMammalian Cells (Bernard Massie). Transformation of Plants (Johannes Siemens). Transient gene expression in mammalian cells (DavidHacker). Transketolases (John Woodley). Tyrosine phenol-lyase (Hidehiko Kumagai).

Vent Gas Analysis (David Pollard). Viral Vaccine Production in Cell Culture (JohnAunins). Virus Removal From Plants (John Sherwood). Virus Retentive Filters (Hazel Aranha).

Water and Wastewater Treatment: Instrumentation, Control andAutomation (Gustaf Olsson).

EAN: 9780471799306
ISBN: 0471799300
Publisher: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
Dimensions: 45 x 31 x 22.5 centimetres (14.63 kg)
Age Range: 15+ years

About the Author

Dr. Michael C. Flickinger is the Associate Director forAcademic Programs of the Golden LEAF Biomanufacturing Training andEducation Center (BTEC) and a Professor of Microbiology andChemical and Biomolecular Engineering at North Carolina StateUniversity, Raleigh. From 1985 to 1992 Dr. Flickinger was Director of the University ofMinnesota's Institute for Advanced Studies in Biological ProcessTechnology (BPTI), which was later renamed the BiotechnologyInstitute (BTI), and a Professor of Biochemistry, Molecular Biologyand Biophysics at the University of Minnesota, St. Paul. Prior tocoming to Minnesota Dr. Flickinger was Director of the FermentationProgram at the National Cancer Institute in Frederick,Maryland. Dr. Flickinger received his academic training at the University ofWisconsin, Madison. He graduated with honors earning a B.S. degreein microbial biochemistry in 1973. He then moved to the School ofPharmacy for his graduate work and received M.S. (1975) and Ph.D.degrees (1977) in pharmaceutical biochemistry. He did hispostdoctoral work at the Laboratory for Renewable ResourcesEngineering (LORRE) in the School of Chemical Engineering, PurdueUniversity, West Lafayette, Indiana. He is Co-Editor of the Encyclopedia of Bioprocess Technology:Fermentation, Biocatalysis and Bioseparation (Wiley, 1999).


This seven-volume, 4,900-page reference resource for industrial biotechnology is a tour de force The nearly 700 contributing authors deliver well-referenced, quality monographs covering both broad and narrow topics in industrial biology, biochemistry, engineering, marketing, microbiology, and processing. ( Choice, 1 November 2010)

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