Table of Contents

Basics
Introduction
The problem of missing data
Concepts of MCAR, MAR and MNAR
Simple solutions that do not (always) work
Multiple imputation in a nutshell
Goal of the book
What the book does not cover
Structure of the book
Exercises

Multiple imputation
Historic overview
Incomplete data concepts
Why and when multiple imputation works
Statistical intervals and tests
Evaluation criteria
When to use multiple imputation
How many imputations?
Exercises

Univariate missing data
How to generate multiple imputations
Imputation under the normal linear normal
Imputation under non-normal distributions
Predictive mean matching
Categorical data
Other data types
Classification and regression trees
Multilevel data
Non-ignorable methods
Exercises

Multivariate missing data
Missing data pattern
Issues in multivariate imputation
Monotone data imputation
Joint Modeling
Fully Conditional Specification
FCS and JM
Conclusion
Exercises

Imputation in practice
Overview of modeling choices
Ignorable or non-ignorable?
Model form and predictors
Derived variables
Algorithmic options
Diagnostics
Conclusion
Exercises

Analysis of imputed data
What to do with the imputed data?
Parameter pooling
Statistical tests for multiple imputation
Stepwise model selection
Conclusion
Exercises

Case studies
Measurement issues
Too many columns
Sensitivity analysis
Correct prevalence estimates from self-reported data
Enhancing comparability
Exercises

Selection issues
Correcting for selective drop-out
Correcting for non-response
Exercises

Longitudinal data
Long and wide format
SE Fireworks Disaster Study
Time raster imputation
Conclusion
Exercises

Extensions
Conclusion
Some dangers, some do's and some don'ts
Reporting
Other applications
Future developments
Exercises

Appendices: Software
R
S-Plus
Stata
SAS
SPSS
Other software

References
Author Index
Subject Index

Reviews

"As an applied biostatistician, the introductory chapter spoke directly to me. It began motivating the issues in multiple imputation from the perspective of applied data problems and problematic approaches to them…Foundational examples start with simple scenarios that are gradually and clearly expanded upon. At each step, R code is shown and illustrations visually show the effects of different approaches. For every major concept there is a half-page "Algorithm Box", a short summary in pseudo-code of the algorithm being discussed. These, in conjunction with the explanatory text, made things extremely clear and easy to grasp… Overall, this book does an excellent job of bringing one from no knowledge of multiple imputation to a working knowledge of multiple imputation."
—ISCB News, July 2016 "The opening chapters of this book will be useful to the newcomer to missing data, including the nonstatistician. Many of the recommendations in the `Do’s and don’ts’ section will be useful to the researcher who encounters missing data and wishes to deal with it responsibly. Finally, the code examples provide a reassuring companion to the user of the mice software package."
—Biometrical Journal, 2014 "This book would be well suited as a textbook, especially at the graduate level, possibly for biostatisticians, epidemiologists, or applied scientists and users of statistical methodology. …a very enjoyable read, and—at least in my opinion—it is a book that belongs on everyone’s shelf as it does open one’s eyes to a problem that has surrounded us (and that many of us have ignored!) for a very long time."
—Wolfgang S. Jank, Journal of the American Statistical Association, June 2013 "From the first lines of Chapter 1 throughout the entire monograph, the author presents numerous R language codes, so the book also serves as a good introduction to R. Each chapter is complete with various examples and exercises. The book is very useful to graduate students and researchers for solving practical problems with real data."
—Technometrics, February 2013 "It’s excellent and I highly recommend it. … van Buuren’s book is great even if you don’t end up using the algorithm described in the book … he supplies lots of intuition, examples, and graphs."
—Andrew Gelman, Columbia University "… a beautiful book that is so full of guidance for statisticians … exceptionally up to date and has more useful wisdom about dealing with common missing data problems than any other source I've seen."
—Frank Harrell, Vanderbilt University "I’m delighted to see this new book on multiple imputation by Stef van Buuren …This book represents a 'no nonsense' straightforward approach to the application of multiple imputation. I particularly like Stef’s use of graphical displays … It’s great to have Stef’s book on multiple imputation, and I look forward to seeing more editions as this rapidly developing methodology continues to become even more effective at handling missing data problems in practice."
—From the Foreword by Donald B. Rubin