Immune Responses to Viral Vectors Used in Gene Therapy
Basic and Clinical Perspectives (Current Topics in Microbiology and Immunology)
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|Format:||Hardback, 240 pages|
|Published In: ||United States, 01 January 2007|
Table of Contents
Can the creativeness of gene therapists overcome the evolutionary advantage of the immune system? Gene therapy as clinical pharmacology and treatment of disease: Quo vadis?- Introductory overview: How the immune responses to viruses informs the use of viral vectors in gene therapy.- Immune responses to adenoviral vectors in the brain.- Innate and adaptive immune responses to adenoviral vectors administered systemically: cellular and molecular mechanisms.- The immune responses to adenoviral vectors: the clinical experience.- Immune responses to AAV vectors in the CNS.- Immune responses to AAV: experimental approaches and clinical implications.- Immune control of HSV: implications for gene therapy.- Immune responses to HSV vectors: implications for clinical trials of brain tumors.- Immune responses to HSV1-derived amplicon vectors.- Control of immune responses to lentiviral vectors administered systemically.- Innate immune responses to retroviral vectors.- The genetics of the immune responses to viral vectors in gene therapy.- Induction of tolerance to gene therapy and therapeutic products.
|Publisher: ||Springer-Verlag New York Inc.|