Nina Proudman's (Asher Keddie) career as an obstetrician is full of surprises, her ex-husband is an explosives expert who detonates to demonstrate his undying love for her, her family life is never short of emergencies, and Nina is the person everyone turns to for help in the midst of their crises. Charting her way through the Proudman maelstrom, Nina is totally thrown off course when she meets dreamy new workmate Chris Havel.

Newly arrived in Melbourne, Chris Havel (Don Hany) is a pediatrician. From the moment he arrives in the neonatal ward, the spark between Chris and Nina ignites. He is everything she could ever want from a man. Chris is handsome and smart, gentle and strong. The two of them seem made for each other. But Chris has a past that could destroy any hope for Nina. Billie Proudman (Kat Stewart) is Nina's unruly elder sister. An apprentice in their father's real estate business, Billie is bold, brassy and incapable of lying. Once the wild child, Billie is now determined to put her wayward youth behind her and make something great of her life. If only she could convince her on again, off again boyfriend Mick (Eddie Perfect) to do the same.