1. Introduction
2. Drug Discovery, Design, and Development
3. Receptors
4. Enzymes (Catalytic Receptors)
5. Enzyme Inhibition and Inactivation
6. DNA-Interactive Agents
7. Drug Metabolism
8. Prodrugs and Drug Delivery Systems
* Organic chemist's perspective of how drugs are designed and
function
* Teaches organic chemists and biochemists the fundamentals of drug
design and drug action using drugs as examples
* Extensive use of references to the primary and secondary
literature for more in depth reading about all concepts
* Extensive use of structures, schemes, and figures to illustrate
points
* Explanations of dual-acting drugs
* Problem sets and answers for each topic
* Casual writing style
* Author has published over 200 articles in the areas of synthesis,
bioorganic chemistry, and medicinal chemistry, has been awarded 21
patents, and has invented a drug that is under consideration for
commercialization.
Professor Richard B. Silverman received his B.S. degree in
chemistry from The Pennsylvania State University in 1968 and his
Ph.D. degree in organic chemistry from Harvard University in 1974
(with time off for a two-year military obligation from 1969-1971).
After two years as a NIH postdoctoral fellow in the laboratory of
the late Professor Robert Abeles in the Graduate Department of
Biochemistry at Brandeis University, he joined the chemistry
faculty at Northwestern University. In 1986, he became Professor of
Chemistry and Professor of Biochemistry, Molecular Biology, and
Cell Biology. In 2001, he became the Charles Deering McCormick
Professor of Teaching Excellence for three years, and since 2004 he
has been the John Evans Professor of Chemistry. His research can be
summarized as investigations of the molecular mechanisms of action,
rational design, and syntheses of potential medicinal agents acting
on enzymes and receptors.
His awards include DuPont Young Faculty Fellow (1976), Alfred P.
Sloan Research Fellow (1981-1985), NIH Research Career Development
Award (1982-1987), Fellow of the American Institute of Chemists
(1985), Fellow of the American Association for the Advancement of
Science (1990), Arthur C. Cope Senior Scholar Award of the American
Chemical Society (2003), Alumni Fellow Award from Pennsylvania
State University (2008), Medicinal Chemistry Hall of Fame of the
American Chemical Society (2009), the Perkin Medal from the Society
of Chemical Industry (2009), the Hall of Fame of Central High
School of Philadelphia (2011), the E.B. Hershberg Award for
Important Discoveries in Medicinally Active Substances from the
American Chemical Society (2011), Fellow of the American Chemical
Society (2011), Sato Memorial International Award of the
Pharmaceutical Society of Japan (2012), Roland T. Lakey Award of
Wayne State University (2013), BMS-Edward E. Smissman Award of the
American Chemical Society (2013), the Centenary Prize of the Royal
Society of Chemistry (2013), and the Excellence in Medicinal
Chemistry Prize of the Israel Chemical Society (2014).
Professor Silverman has published over 320 research and review
articles, holds 49 domestic and foreign patents, and has written
four books (The Organic Chemistry of Drug Design and Drug Action is
translated into German and Chinese). He is the inventor of
LyricaTM, a drug marketed by Pfizer for epilepsy, neuropathic pain,
fibromyalgia, and spinal cord injury pain; currently, he has
another CNS drug in clinical trials.
"...this text is directed towards graduates who are embarking on a
career in medicinal chemistry in the discovery laboratory.
Sliverman continues to blur the edges between chemistry and
pharmacology in a manner that is incontrovertibly relevant to the
discipline of drug design and development." --Michael E. Cooper, GE
Healthcare, The Maynard Centre, in DDT, VOL. 9, 2004
"What stands out in comparison with other books discussed here is
that the subjects are generally addressed in detail, and each
theoretical point is illustrated with examples of specific drugs. A
great deal of knowledge is reflected...that is suitable for both
advanced students and PhDs a like who have not yet become
acquainted with the area, but who wish to prepare themselves for a
career in drug research." --ORGANIC CHEMISTRY ORG., 2005
Praise for the First Edition: "This book is a tour de force in the
title area...This book would be appropriate for advanced
undergraduate students and graduate students...strongly recommended
to scientists who are seeking an efficient introduction to
medicinal chemistry, background in a specific drug principle or
category, or a dose of inspiration." --JOURNAL OF THE AMERICAN
CHEMICAL SOCIETY
"... unified, well-organized and clearly presented ...It is so
clearly written that it will be of value to both students and
veteran scientists...My congratulations to Dr. Silverman in
consolidating such a multiplicity of facts and data so as to truly
begin to reduce medicinal chemistry from a hybrid of chemistry,
pharmacology and related sciences to a single, clearly defined,
rationalized discipline." --Carl Kaiser, Director of Medicinal
Chemistry, NOVA PHARMACEUTICAL CORPORATION
"The author shows an uncanny ability to present the salient
principles in a systematic, well-balanced and logical way..."
--William C. Groutas, WICHITA STATE UNIVERSITY
"I was favorably impressed with the clarity of Dr. Silverman's
writing style which made the material interesting and easy to
read...Treatment of the material is quite comprehensive without
being overly detailed and the referencing and illustrations are
well chosen..." --John G. Topliss, PARKE-DAVIS
"...The organization of this book and the clarity of presentation
are outstanding... It is highly recommended to medicinal chemists
as well as to all others entering into the field or concerned with
the science of medicinal chemistry." --JOURNAL OF MEDICINAL
CHEMISTRY Praise for the new edition: "...intent of the first
edition was to provide a textbook for advanced undergraduate
students or graduate students, the scope of the second edition has
been expanded so that it not only serves the original purpose but
also serves as an excellent reference book for practicing medicinal
chemists." --John W. Ellingboe, Wyeth Research for the Journal of
Medicinal Chemistry, 2004 "...this book is a thorough overview of
drug discovery and development... It is not only an excellent
textbook for students but also a valuable resource for those
already practicing medicinal chemistry." --John W. Ellingboe, Wyeth
Research for the Journal of Medicinal Chemistry, 2004
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