Table of Contents

SECTION I CLINICAL TRIAL PRINCIPLES CH. 1 Randomized Clinical Trials CH. 2 Designing Clinical Trials CH. 3 Randomization: What It Is and How to Do It CH. 4 Setting Sample Size for Randomized Clinical Trials CH. 5 Analytic Approach and Methods CH. 6 Ethical Considerations SECTION II Large Multicenter Trials: Structure and Conduct CH. 7 Study Organization and Governance CH. 8 Quality Control and Quality Assurance CH. 9 Quality Assurance: Prevention of Missing Data SECTION III THE FUTURE CH. 10 Surrogate Endpoints CH. 11 Registries CH. 12 Gazing Into the Crystal Ball: The Future of Randomized Clinical Trials INDEX