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Table of Contents

Section 1: Cellular Physiology 1. Principles of Cell and Membrane Function 2. Homeostasis: Volume and Composition of Body Fluid Compartments 3. Signal Transduction, Membrane Receptors, Second Messengers, and Regulation of Gene Expression Section 2: The Nervous System 4. The Nervous System: Introduction to Cells and Systems 5. Generation and Conduction of Action Potentials 6. Synaptic Transmission 7. The Somatosensory System 8. The Special Senses 9. Organization of Motor Function 10. Higher Functions of the Nervous System 11. The Autonomic Nervous System and Its Central Control Section 3: Muscle 12. Skeletal Muscle Physiology 13. Cardiac Muscle 14. Smooth Muscle Section 4: The Cardiovascular System 15. Overview of Circulation 16. Elements of Cardiac Function 17. Properties of the Vasculature 18. Regulation of the Heart and Vasculature 19. Integrated Control of the Cardiovascular System Section 5: The Respiratory System 20. Structure and Function of the Respiratory System 21. Static Lung and Chest Wall Mechanics 22. Dynamic Lung and Chest Wall Mechanics 23. Ventilation (V.), Perfusion (Q.), and V./Q. Relationships 24. Oxygen and Carbon Dioxide Transport 25. Control of Respiration 26. Nonrespiratory Functions of the Lung Section 6: Gastrointestinal Physiology 27. Functional Anatomy and General Principles of Regulation in the Gastrointestinal Tract 28. The Cephalic, Oral, and Esophageal Phases of the Integrated Response to a Meal 29. The Gastric Phase of the Integrated Response to a Meal 30. The Small Intestinal Phase of the Integrated Response to a Meal 31. The Colonic Phase of the Integrated Response to a Meal 32. Transport and Metabolic Functions of the Liver Section 7: The Renal System 33. Elements of Renal Function 34. Solute and Water Transport along the Nephron: Tubular Function 35. Control of Body Fluid Osmolality and Volume 36. Potassium, Calcium, and Phosphate Homeostasis 37. Role of the Kidneys in the Regulation of Acid-Base Balance Section 8: The Endocrine and Reproductive Systems 38. Introduction to the Endocrine System 39. Hormonal Regulation of Energy Metabolism 40. Hormonal Regulation of Calcium and Phosphate Metabolism 41. The Hypothalamus and Pituitary Gland 42. The Thyroid Gland 43. The Adrenal Glands 44. The Male and Female Reproductive Systems

About the Author

Bruce Koeppen, founding dean of the Frank H. Netter MD School of Medicine at Quinnipiac, recently received two prestigious awards: honored by the Patient is U Foundation - a nonprofit that aims to encourage human communication in health care and support both patients and providers and the (LCME) Liaison Committee on Medical Education's 2019 Distinguished Service Award. Bruce Stanton received the Unsung Hero Award in 2019 from the Cystic Fibrosis Foundation. He played a key role in the development of Vertex modulators and is connected with sparking the creation of a Patient Registry which has had an enormous impact on the length and quality of lives in CF patients.


This physiology textbook will continue to be one of the standards for medical education for the foreseeable future. - The Physiologist, review of the previous edition

This substantial American physiology text looks at everything from cells and the nervous system to muscles and the cardiovascular, respiratory, gastrointestinal, renal endocrine and reproductive systems...Overall, this is a source of reliable information on systems-based physiology.

Nursing Standard, April 2010

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