Preface vi
1 Introduction 1
2 Mechanisms of acquired QT prolongation and torsades de pointes 8
3 Measurement of the QT interval and repolarization assessment 24
4 Introduction to drug-induced long QT syndrome 60
5 Risk of QT prolongation and torsades de pointes with antiarrhythmic drugs 69
6 Risk of QT prolongation and torsades de pointes with antihistamines 87
7 Risk of QT prolongation and torsades de pointes with psychotropic drugs 102
8 Risk of QT prolongation and torsades de pointes with antimicrobial and antimalarial drugs 121
9 Risk of QT prolongation and torsades de pointes with prokinetics and miscellaneous other drugs 140
10 Acquired long QT syndrome secondary to cardiac conditions 163
11 Acquired long QT syndrome secondary to noncardiac conditions 171
12 Perspective on drug-induced repolarization changes 182
Index 191
A. John Camm, MD, FRCP, FESC, FACC
Professor of Clinical Cardiology and Head, Department of
Cardiological Sciences, St. George’s Hospital Medical School,
London
Marek Malik, PhD, MD, DSc, FACC, FECS
Professor of Cardiac Electrophysiology, Department of Cardiological
Sciences, St. George’s Hospital Medical School, London
Yee Guan Yap, BMedSci, MBBS, MRCP
British Heart Foundation Research Fellow in Cardiology, Department
of Cardiological Sciences, St. George’s Hospital Medical School,
London
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