L.B. Kier and B. Testa, Complexity and Emergence in Drug Research. M.S. Tute, Drug Design: the Present and the Future. K. Burki and B. Ledermann, Transgenic Animals as Pharmacological Tools. C.L. Crespi, Xenobiotic-metabolizing Human Cells as Tools for Pharmacological and Toxicological Research. J. Urquhart, Correlates of Variable Patient Compliance in Drug Trials: Relevance in the New Health Care Environment. Subject Index. Cumulative Index of Authors. Cumulative Index of Titles.