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Advances and Future Directions in the Pathogenesis and Therapy of Rheumatoid Arthritis, an Issue of Rheumatic Disease Clinics (The Clinics
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There are numerous monographs devoted to rheumatoid arthritis.� What sets this issue apart is that it keeps an eye to the future.� Topics explored include measurement of RA disease activity today and in the future; epidemiology of RA - implications for prevention and risk assessment; genes that predispose to RA - relevance to current and future therapeutic strategies; multiple kinases - assessment of the best targets in treating RA; assessment, prevention and treatment of cardiovascular morbidity in RA; mechanistic insights and approaches to prevention of bone damage in RA; cell-cell interactions in RA synovium as potential new targets for treatment; alternative strategies for modulating the function of B lymphocytes in RA; innate immunity in RA; ascertainment and management of preclinical RA.
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D. Fox is Senior Director in the CTO Office of Dassault Systemes SIMULIA. He has more than 26 years' experience in the research and development of finite element technology.

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