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Contents: J.S. Grotstein, Foreword. Preface. Part I:Background and Overview. Introduction. General Principles of Growth of the Developing Brain. Recent Advances in the Multidisciplinary Study of Emotional Development. Structure-Function Relationships of the Orbitofrontal Cortex. Overview. Part II:Early Infancy. Visual Experiences and Socioemotional Development. The Practicing Period. The Psychobiology of Affective Reunions. Early Imprinting. Imprinting Neuroendocrinology. Socioaffective Influences on Orbitofrontal Morphological Development. The Emotionally Expressive Face. The Neurochemical Circuitry of Imprinted Interactive Representations. The Regulatory Function of Early Internal Working Models. Part III:Late Infancy. The Onset of Socialization Procedures and the Emergence of Shame. Late Orbitofrontal Development. Orbitofrontal Versus Dorsolateral Prefrontal Ontogeny. The Dyadic Origin of Internal Shame Regulation. Socialization and Experience-Dependent Parcellation. The Origins of Infantile Sexuality and Psychological Gender. The Onset of Dual Component Orbitofrontal Mature Structure and Adaptive Function. Part IV:Applications to Affect Regulatory Phenomena. A Psychoneurobiological Model of the Dual Circuit Processing of Socioemotional Information. Cross-Modal Transfer and Abstract Representations. The Development of Increasingly Complex Interactive Representations. Orbitofrontal Influences on the Autonomic Nervous System. The Regulation of Infantile Rage Reactions. Affect Regulation and Early Moral Development. The Emergence of Self-Regulation. Part V:Clinical Issues. The Neurobiology of Insecure Attachments. The Clinical Psychiatry of Affect Dysregulation. The Developmental Psychopathology of Personality Disorders. Vulnerability to Psychosomatic Disease. Psychotherapy of Developmental Disorders. Part VI:Integrations. Right Hemispheric Language and Self-Regulation. The Dialogical Self and the Emergence of Consciousness. Further Directions of Multidisciplinary Study. A Proposed Rapprochement Between Psychoanalysis and Neurobiology.