Table of Contents

AUTHORS' APPOINTMENTS vii

1. INTRODUCTION 1
Philip M Preece

SECTION 1. NEUROTERATOGENESIS – EPIDEMIOLOGY AND PATHOLOGY

2. EPIDEMIOLOGY OF DRUG AND ALCOHOL USE DURING PREGNANCY 11
Ron Gray

3. NORMAL AND ABNORMAL EMBRYOGENESIS OF THE MAMMALIAN BRAIN 23
Kathy K Sulik, Shonagh K O'Leary-Moore, Elizabeth A Godin and Scott E Parnell

SECTION 2. LONG-TERM EFFECTS OF MAJOR PRESCRIBED MEDICATIONS

4. EPILEPSY IN PREGNANCY AND THE EFFECT OF PRENATAL ANTIEPILEPTIC MEDICATION 44
Jill Clayton-Smith and Gus Baker

5. NEURODEVELOPMENT OF CHILDREN EXPOSED TO ANTIDEPRESSANT AND ANTIPSYCHOTIC MEDICATIONS DURING PREGNANCY 56
Irene Nulman, Sara Citron, Michelle Todorow and Elizabeth Uleryk

SECTION 3. LONG-TERM EFFECTS OF DRUGS OF ABUSE

6. DIAGNOSIS OF FETAL ALCOHOL SYNDROME: EMPHASIS ON EARLY DETECTION 85
Margaret Barrow and Edward P Riley

7. THE EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON BRAIN AND BEHAVIOUR 108
Christie L McGee Petrenko and Edward P Riley

8. EFFECT OF DRUGS OF ABUSE ON THE FETUS: COCAINE AND OPIATES INCLUDING HEROIN 130
Lynn T Singer and Sonia Minnes

9. CANNABIS USE DURING PREGNANCY: ITS EFFECTS ON OFFSPRING FROM BIRTH TO YOUNG ADULTHOOD 153
Peter A Fried

10. IN UTERO EXPOSURE TO THE POPULAR 'RECREATIONAL' DRUGS MDMA (ECSTASY) AND METHAMPHETAMINE (ICE, CRYSTAL): PRELIMINARY FINDINGS 169
Derek G Moore, John J D Turner, Julia E Goodwin, Sarah E Fulton, Lynn T Singer and Andrew C Parrott

11. THE SHORT-TERM AND LONG-TERM DEVELOPMENTAL CONSEQUENCES OF MATERNAL SMOKING DURING PREGNANCY 183
Kate E Pickett and Lauren S Wakschlag

SECTION 4. INTERVENTION STRATEGIES TO REDUCE THE IMPACT OF DRUGS AND ALCOHOL IN PREGNANCY

12. MANAGEMENT OF THE EFFECTS OF PRENATAL DRUGS IN CHILDREN OF DRUG-ABUSING PARENTS 197
Faye Macrory and Michael Murphy

13. PRENATAL AND POSTNATAL INTERVENTION STRATEGIES FOR ALCOHOL-ABUSING MOTHERS IN PREGNANCY 217
Ann P Streissguth and Therese M Grant

14. COGNITIVE AND BEHAVIOURAL INTERVENTIONS TO AMELIORATE THE EFFECTS OF FETAL ALCOHOL SPECTRUM DISORDERS IN CHILDREN AND ADOLESCENTS: PROMOTING POSITIVE OUTCOMES 234
Wendy O Kalberg and Julie Gelo

15. FETAL TERATOGEN SYNDROMES: PSYCHIATRIC ASPECTS AND MANAGEMENT 252
David J Bramble and Raja A S Mukherjee

16. RECOMMENDED MANAGEMENT OF COMMON MEDICAL PROBLEMS IN PREGNANCY: ADVICE FROM SPECIALIST AGENCIES 271
Evelyne Jacqz-Aigrain and Philip M Preece

INDEX 280

COLOUR PLATE SECTION

About the Author

Philip Preece is a consultant paediatrician with training in neurodisability. He manages a range of children with autism spectrum disorders, attention-deficit hyperactivity disorder, and learning difficulties. He has developed an interest in the outcome of infants exposed to prenatal drugs, both medicinal and recreational, as part of his work assessing children prior to adoption. Ed Riley served as Chair of the National Task Force on Fetal Alcohol Syndrome/Fetal Alcohol Effect. He currently serves as the Steering Committee Co-Chair of the Fetal Alcohol Spectrum Disorders Center for Excellence. He has been President of the Research Society on Alcohol, the Fetal Alcohol Study Group, and the Behavioral Teratology Society. He has served as Associate Editor of the Journal of Studies on Alcohol , and is on the Editorial Boards of Alcoholism: Clinical and Experimental Research and the Psychological Record . He has received numerous awards for his scholarship and service, most recently the Research Society on Alcoholism Distinguished Researcher Award.