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Alzheimer's Disease
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Alzheimer's disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer's Disease: A Physician's Guide to Practical Management was written by selected clinicians and scientists who represent some of the world's leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.
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Table of Contents

Part I. Scientific Background of Alzheimer's Disease Genetics of Alzheimer's Disease and Related Disorders John Hardy Neuropathology of Alzheimer's Disease Christian Schultz, Kelly Del Tredici, and Heiko Braak Oxidative Stress in the Development of Alzheimer's Disease and Other Dementias Domenico Pratico Metabolism and Alzheimer's Disease John P. Blass Part II. Epidemiology Alzheimer's Disease: Epidemiological and Statistical Data Brigitte Zoeller Richter and Ralph W. Richter The Economic Burden of Alzheimer's Disease and Dementia Anders Wimo and Bengt Winblad Potential and Established Risk Factors for Alzheimer's Disease Brigitte Zoeller Richter Part III. Clinical Assessment Medical Diagnosis and Workup of Alzheimer's Disease Ralph W. Richter Neuroimaging Techniques: CT, MRI, SPECT, PET Norman L. Foster Biological Markers in Alzheimer's Disease Ramon Diaz-Arrastia and Fred Baskin The Neuropsychology of Alzheimer's Disease Kirsten I. Taylor and Andreas U. Monsch Vascular Cognitive Impairment in Clinical Practice Kenneth Rockwood and Timo Erkinjuntti Lewy Body Disease Robert Barber, Jane Newby, and Ian G. McKeith Frontotemporal Lobe Dementia Malgorzata Franczak, Diana Kerwin, and Piero Antuono Part IV. The Transitional Stage Mild Forgetfulness: Distinguishing Early AD from Normal Aging Scott A. Small Mild Cognitive Impairment: What the Physician Should Know Brigitte Zoeller Richter Diagnosis of Predementia AD in a Clinical Setting Pieter Jelle Visser Loss of Olfactory Function in Patients With Alzheimer's Disease Claire Murphy and Paul E. Gilbert Part V. Treatment Options Treatment of Alzheimer's Disease: BasicConsiderations Brigitte Zoeller Richter and Ralph W. Richter Donepezil in Treatment of AD Ging-Yuek Robin Hsiung and Howard Feldman Rivastigmine for Treatment of AD Martin R. Farlow Galantamine in Treatment of AD M. Saleem Ismail and Pierre N. Tariot Memantine in Treatment of AD Hans Joerg Moebius Alternative Treatment Options Brigitte Zoeller Richter Part VI. Late-Stage Therapy Pain and Palliative Care in Late-Stage Dementia Patients Sophie Pautex, Dina Zekry, Gilbert Zulian, Gabriel Gold, and Jean-Pierre Michel Cardiological Issues in Late-Stage Alzheimer's Disease: A Clinician's Approach Jose R. Medina Part VII. Prevention Strategies Neuroprotection and Neurodegenerative Disease Frank John Emery Vajda Neurotrophic Factors for Prevention of Alzheimer's Disease Mark H. Tuszynski Statins in Prevention and Treatment of Alzheimer's Disease David A. Drachman Potential Role of Androgens and Androgen Receptors in Alzheimer's Disease Jacob Raber Role of Nutrition in Prevention or Delay of Alzheimer's Disease Hannes B. Staehelin Impact of Physical Activity on Prevention of Alzheimer's Disease Danielle Laurin, Rene Verreault, and Joan Lindsay Part VIII. Future Developments Stem Cell Therapy for Alzheimer's Disease Kiminobu Sugaya Secretases as Potential Targets for Treatment of Alzheimer's Disease Weiming Xia AMPA Potentiation as a Treatment Option for Alzheimer's Disease Amy S. Chappell and Michael M. Witte Glycosaminoglycans as Potential Future Treatment of Alzheimer's Disease Umberto Cornelli Implications of Research for Management of AD Peter J. Whitehouse Part IX. Treatment Outcome Measurement Rating Scales and Outcome

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Reviews

"This is an easy-to-read and accessible book that presents an impressive amount of detail and information. It will appeal to physicians who want more background and detail as they approach their Alzheimer's patients, rather than just a simple "cookbook" recipe for treatment. Chapters on new and evolving treatments are well done and offer a glimpse of the future. Physicians who establish specialized clinics or units for the care of Alzheimer's patients will find this book especially useful."-Doody's Health Sciences Book Review Journal "...chapters on pathophysiology lucidly explain the evidence supporting the role of oxidative stress, as well as the roles and interrelationships of mutant amyloid precursor protein, presenilin, and tau...The section on clinical assessment provides many clinical pearls that can help the clinician recognize dementias often mistaken for Alzheimer disease." - Annals of Internal Medicine "...a mine of useful information that gives an honest cross-sectional view of our knowledge about dementia." - Institute for Ageing and Health

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