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Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardiac biomechanics, the mechanics of blood vessels, cochlear mechanics, biodegradable biomaterials, soft tissue replacements, cellular biomechanics, neural engineering, electrical stimulation for paraplegia, and visual prostheses. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.
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Table of Contents

PHYSIOLOGIC SYSTEMS An Outline of Cardiovascular Structure and Function; Daniel J. Schneck Kidney Structure and Physiology; Joel M. Henderson and Mostafa Belghasem Nervous System; Evangelia Micheli-Tzanakou Vision System; Aaron P. Batista and George D. Stetten Auditory System; Ben M. Clopton and Herbert F. Voigt Gastrointestinal System; Berj L. Bardakjian Respiratory System; Arthur T. Johnson, Christopher G. Lausted, and Joseph D. Bronzino BIOMECHANICS Mechanics of Hard Tissue; J. Lawrence Katz, Anil Misra, Orestes Marangos, Qiang Ye, and Paulette Spencer Musculoskeletal Soft-Tissue Mechanics; Richard L. Lieber, Samuel R. Ward, and Thomas J. Burkholder Joint-Articulating Surface Motion; Kenton R. Kaufman and Kai-Nan An Joint Lubrication; Michael J. Furey Analysis of Gait; Roy B. Davis, III, Sylvia Ounpuu, and Peter A. DeLuca Mechanics of Head/Neck; Albert I. King and David C. Viano Biomechanics of Chest and Abdomen Impact; David C. Viano and Albert I. King Cardiac Biomechanics; Andrew D. McCulloch and Roy C.P. Kerckhoffs Heart Valve Dynamics; Choon Hwai Yap, Erin Spinner, Muralidhar Padala, and Ajit P. Yoganathan Arterial Macrocirculatory Hemodynamics; Baruch B. Liber Mechanics of Blood Vessels; Thomas R. Canfield and Philip B. Dobrin The Venous System; Artin A. Shoukas and Carl F. Rothe The Microcirculation Physiome; Aleksander S. Popel and Roland N. Pittman Mechanics and Deformability of Hematocytes; Richard E. Waugh and Robert M. Hochmuth Mechanics of Tissue/Lymphatic Transport; Geert W. Schmid-Schoenbein and Alan R. Hargens Modeling in Cellular Biomechanics; Alexander A. Spector and Roger Tran-Son-Tay Cochlear Mechanics; Charles R. Steele and Sunil Puria Inner Ear Hair Cell Bundle Mechanics; Jong-Hoon Nam and Wally Grant Exercise Physiology; Cathryn R. Dooly and Arthur T. Johnson Factors Affecting Mechanical Work in Humans; Ben F. Hurley and Arthur T. Johnson BIOMATERIALS Metallic Biomaterials; Joon B. Park and Young Kon Kim Ceramic Biomaterials; W.G. Billotte Polymeric Biomaterials; Hai Bang Lee, Gilson Khang, and Jin Ho Lee Composite Biomaterials; Roderic S. Lakes Biodegradable Polymeric Biomaterials: An Updated Overview; C.C. Chu Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen); Shu-Tung Li Biologic Biomaterials: Silk; Biman Mandal and David L. Kaplan Biofunctional Hydrogels; Melissa K. McHale and Jennifer L. West Soft Tissue Replacements; K.B. Chandran, K.J.L. Burg, and S.W. Shalaby Hard Tissue Replacements; Sang-Hyun Park, Adolfo Llinas, and Vijay K. Goel BIOELECTRIC PHENOMENA Basic Electrophysiology; Roger C. Barr Volume Conductor Theory; Robert Plonsey Electrical Conductivity of Tissues; Bradley J. Roth Cardiac Microimpedances; Andrew E. Pollard Membrane Models; Anthony Varghese Computational Methods and Software for Bioelectric Field Problems; Christopher R. Johnson The Potential Fields of Triangular Boundary Elements; A. van Oosterom Principles of Electrocardiography; Edward J. Berbari Electrodiagnostic Studies; Sanjeev D. Nandedkar Principles of Electroencephalography; Joseph D. Bronzino Biomagnetism; Jaakko Malmivuo Electrical Stimulation of Excitable Tissue; Dominique M. Durand NEUROENGINEERING History and Overview of Neural Engineering; Daniel DiLorenzo and Robert E. Gross Theory and Physiology of Electrical Stimulation of the Central Nervous System; Warren M. Grill Transcutaneous FES for Ambulation: The Parastep System; Daniel Graupe Comparing Electrodes for Use as Cortical Control Signals: Tines, Wires, or Cones on Wires-Which Is Best?; Philip R. Kennedy Development of a Multifunctional 22-Channel Functional Electrical Stimulator for Paraplegia; R. Davis, T. Johnston, B. Smith, R. Betz, T. Houdayer, and A. Barriskill An Implantable Bionic Network of Injectable Neural Prosthetic Devices: The Future Platform for Functional Electrical Stimulation and Sensing to Restore Movement and Sensation; J. Schulman, P. Mobley, J. Wolfe, R. Davis, and I. Arcos Visual Prostheses; Robert J. Greenberg Interfering with the Genesis and Propagation of Epileptic Seizures by Neuromodulation; Ana Luisa Velasco, Francisco Velasco, Marcos Velasco, Bernardo Boleaga, Mauricio Kuri, Fiacro Jimenez, and Jose Maria Nunez Transcranial Magnetic Stimulation of Deep Brain Regions; Yiftach Roth and Abraham Zangen

About the Author

Joseph D. Bronzino is the founder and president of the Biomedical Engineering Alliance and Consortium (BEACON) in Hartford, Connecticut. He earned a PhD in electrical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Bronzino has received the Millennium Award from IEEE/EMBS and the Goddard Award from Worcester Polytechnic Institute for Professional Achievement. He is the author of more than 200 articles and 11 books. Donald R. Peterson is a professor of engineering and dean of the College of Science, Technology, Engineering, Mathematics, and Nursing at Texas A&M University-Texarkana. He earned a PhD in biomedical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Peterson's recent research focuses on measuring and modeling human, organ, and/or cell performance, including exposures to various physical stimuli and the subsequent biological responses. Dr. Peterson has published more than 50 journal articles and 12 reference books.

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