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Table of Contents

Author Biographies Introduction: the measurement interface between physical and life Infrared spectroscopy Raman spectroscopy Biomedical spectroscopy Vibrational biomedical spectroscopy of cells Vibrational biomedical spectroscopy of fluids Vibrational biomedical spectroscopy of tissue The Future is Bright

About the Author

Matt Baker obtained his PhD from the Department of Chemical Engineering and Analytical Science, University of Manchester based in the Manchester Interdisciplinary Biocentre. Following this he was awarded an EPSRC Fellowship conducting research at the Robert Koch Institute and Harvard Medical School. He was then a Project Manager, Senior Scientist and Research Fellow for Dstl and Senior Lecturer at UCLan. He is currently a Senior Lecturer in the Department of Pure and Applied Chemistry, University of Strathclyde based in the Technology and Innovation Centre. His research aims are to understand the composition and behaviour of molecules within complex matrices related to real-world detection challenges with a specific focus on developing spectroscopic biofluid diagnostics. Katherine Hollywood obtained her PhD from the School of Chemistry at the University of Manchester, UK, under the supervision of Professor Roy Goodacre. Her PhD was focused on using a variety of analytical techniques to investigate the onset of skin disease. Katherine is currently employed as a PDRA on a BBSRC BRIC funded project that aims to use single cell technologies both spectroscopic and mass spectrometry-based to investigate cell heterogeneity and differentiation, with the aim of detecting and predicting differentiation status. Her research focus continues to use Raman spectroscopy and mass spectrometry-based metabolomics to investigate mammalian systems of clinical and bioprocessing importance, with the overall aim of driving forward the use of novel analytical technologies. Caryn Hughes obtained a Master of Chemistry MChem with Industrial Experience in 2007, followed by an Analytical Science PhD entitled 'Development of FTIR for Drug Response Analysis' at the University of Manchester in 2011. Caryn has since worked as an interdisciplinary Postdoctoral Research Associate in groups including the Genito Urinary Cancer Research Group (led by Professor Noel Clarke) at the Cancer Research UK Manchester Institute, the Analytical and Medical Vibrational Spectroscopy Group at the Manchester Institute of Biotechnology (led by Professor Peter Gardner), the Instrumentation and Analytical Science group (led by Dr Philip Martin) at the University of Manchester and the Spectral Analytics Laboratory (led by Matthew Baker) at the University of Strathclyde. The focus of her research is biomedical infrared spectroscopy, working with biofluids, cells and tissue sample formats for diagnostic and investigative disease state analysis.

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