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Bone Cancer


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Table of Contents

Section 1: Introduction Genetic control, frequencies and epidemiology of bone cancers The incidence and progression of metastatic bone lesions Section 2: Bone microenvironment and bone cancer Bone microenvironment and tumor growth Osteoblast Differentiation and Cell Signalling Osteoclast Differentiation and Function Cytokines in bone remodeling and bone tumors Proteases and bone tumors - therapeutic approaches Section 3: Bone markers Early bone metastasis Bone remodeling markers and bone cancer Proteomic of bone cancers Genomic Alterations in Bone Tumors Biology of bone tumors and new diagnostic tools Gene profiling of osteosarcoma Molecular pathology of osteosarcoma Histopathology of prostate and breast metastases Technical aspects: how do we best prepare bone samples for proper histological analysis? Section 4: Myeloma, odontogenic tumors and bone metastases Multiple myeloma bone diseases Osteolytic lesions Bone metastases of prostatic cancer Bone metastases of breast cancer Section 5: Primary bone tumors Osteosarcoma and osteoblasts: diagnosis and therapy Ewing sarcoma family of tumors: diagnosis and therapy Non-surgical treatment of chondrosarcoma: diagnosis and therapy Chondrosarcoma of bone: diagnosis and therapy Osteoclast-rich lesions of bone: diagnosis and therapy Section 6: Imaging of bone cancers Interventional Radiologic Techniques Imaging of bone metastases Diagnosis of bone metastases Section 7: Pain control in bone cancers Pain control with radiotherapy Mechanisms and management of bone cancer pain Malignant skeletal pain Section 8: New therapeutic advances of bone cancers Primary bone tumors and novel therapeutic approaches Cytokine gene therapy in bone remodeling Bisphosphonates Multi-targeted approach RANKL and targeted therapy Apoptosis and drug resistance

About the Author

Dominique Heymann studied cell biology, biochemistry and immunology in INSERM (French NIH) unit 211 at the University of Nantes and received his Ph.D. in 1995. He was appointed Associate Professor in 2001 in the Department of Histology and Embryology. In 2009, he was awarded a personal Chair of Histology and Embryology.Currently he is the Quality Control Manager of the Tissue Bank and Gene and Cellular Therapy Unit at Nantes Hospital. He heads a laboratory research group (INSERM UMR 957) of 65 people at the Faculty of Medicine, where the pathogenesis of primary bone tumours, and more specifically, the role of bone microenvironment (osteoclasts, mesenchymal stem cells, OPG/RANK/RANKL, IL-6 and MCSF cytokine family) in tumour growth is studied.In 2006, Dominique Heymann won the Paul Mathieu prize from the National Academy of Medicine for his work entitled "From the osteolytic process associated to primary bone tumors to the development of bi-therapies for osteosarcoma". He was on the national scientific advisory board of INSERM (2008-2012) and is now Co-Chairman of INSERM scientific commission n Degrees5 ("Physiology and pathophysiology of endocrine, bone, skin and gastrointestinal tissues"). He has authored approximately 180 publications in peer- reviewed journals, more than 300 abstracts and 20 book chapters. He is also Associate Editor of Life Sciences, Academic Editor of PLoS ONE, Editor-in-Chief of the Open Bone Journal and serves on the Editorial Board of Current Medicine Chemistry, European Journal of Pharmacology, and Journal of Bone Oncology.


"Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic." -- Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King's College London, United Kingdom "Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bone cancer and metastasis, their pathophysiology, diagnosis and treatment. This encompassing book will undoubtedly meet the needs of residents and fellows as well as expert clinicians and scientists." --Roland Baron, Professor, Harvard Medical School, Boston MA, USA

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