Table of Contents

Part I Foundations of Cardiovascular Medicine
1. Cardiovascular Disease: Past, Present, and Future
2. Global Burden of Cardiovascular Disease
3. Impact of the Environment on Cardiovascular Health
4. Clinical Trials in Cardiovascular Medicine
5. Clinical Decision-Making in Cardiology
6. Impact of Health Care Policy on Quality, Outcomes, and Equity in Cardiovascular Disease

Part II Individualizing Approaches to Cardiovascular Disease
7. Applications of Genetics to Cardiovascular Medicine
8. Proteomics and Metabolomics in Cardiovascular Medicine
9. Principles of Drug Therapeutics, Pharmacogenomics, and Biologics
10. Biomarkers and Use in Precision Medicine
11. Artificial Intelligence in Cardiovascular Medicine
12. Wearable Devices in Cardiovascular Medicine

Part III Evaluation of The Patient
13. History and Physical Examination: An Evidence-Based Approach
14. Electrocardiography
15. Exercise Physiology and Exercise Electrocardiographic Testing
16. Echocardiography
17. Chest Radiography in Cardiovascular Disease
18. Nuclear Cardiology
19. Cardiovascular Magnetic Resonance Imaging
20. Cardiac Computed Tomography
21. Coronary Angiography and Intravascular Imaging
22. Invasive Hemodynamic Diagnosis of Cardiac Disease
23. Anesthesia and Noncardiac Surgery in Patients with Heart Disease

Part IV Preventive Cardiology
24. The Vascular Biology of Atherosclerosis
25. Primary Prevention of Cardiovascular Disease
26. Systemic Hypertension: Mechanisms, Diagnosis, and Treatment
27. Lipoprotein Disorders and Cardiovascular Disease
28. Cardiovascular Disease Risk of Nicotine and Tobacco Products
29. Nutrition and Cardiovascular and Metabolic Diseases
30. Obesity: Medical and Surgical Management
31. Diabetes and the Cardiovascular System
32. Exercise and Sports Cardiology
33. Comprehensive Cardiac Rehabilitation
34. Integrative Approaches to the Management of Patients with Heart Disease

Part V Atherosclerotic Cardiovascular Disease
35. Approach to the Patient with Chest Pain
36. Coronary Blood Flow and Myocardial Ischemia
37. ST-Elevation Myocardial Infarction: Pathophysiology and Clinical Evolution
38. ST-Elevation Myocardial Infarction: Management
39. Non-ST Elevation Acute Coronary Syndromes
40. Stable Ischemic Heart Disease
41. Percutaneous Coronary Intervention
42. Diseases of the Aorta
43. Peripheral Artery Diseases
44. Treatment of Noncoronary Obstructive Vascular Disease
45. Prevention and Management of Ischemic Stroke

Part VI Heart Failure
46. Mechanisms of Cardiac Contraction and Relaxation
47. Pathophysiology of Heart Failure
48. Approach to the Patient with Heart Failure
49. Diagnosis and Management of Acute Heart Failure
50. Management of Heart Failure Patients with Reduced Ejection Fraction
51. Heart Failure with Preserved and Mildly Reduced Ejection Fraction
52. The Dilated, Restrictive, and Infiltrative Cardiomyopathies
53. Cardiac Amyloidosis
54. Hypertrophic Cardiomyopathy
55. Myocarditis
56. Cardio-Oncology: Managing Cardiotoxic Effects of Cancer Therapies
57. Cardio-Oncology: Approach to the Patient
58. Devices for Monitoring and Managing Heart Failure
59. Mechanical Circulatory Support
60. Cardiac Transplantation

Part VII Arrhythmias, Sudden Death, and Syncope
61. Approach to the Patient with Cardiac Arrhythmias
62. Mechanisms of Cardiac Arrhythmias
63. Genetics of Cardiac Arrhythmias
64. Therapy for Cardiac Arrhythmias
65. Supraventricular Tachycardias
66. Atrial Fibrillation: Clinical Features, Mechanisms, and Management
67. Ventricular Arrhythmias
68. Bradyarrhythmias and Atrioventricular Block
69. Pacemakers and Implantable Cardioverter-Defibrillators
70. Cardiac Arrest and Sudden Cardiac Death
71. Hypotension and Syncope

Part VIII Diseases of the Heart Valves
72. Aortic Valve Stenosis
73. Aortic Regurgitation
74. Transcatheter Aortic Valve Replacement
75. Mitral Stenosis
76. Mitral Regurgitation
77. Tricuspid, Pulmonic, and Multivalvular Disease
78. Transcatheter Therapies for Mitral and Tricuspid Valvular Heart Disease
79. Prosthetic Heart Valves
80. Infectious Endocarditis and Infections of Indwelling Devices
81. Rheumatic Fever

Part IX Diseases of the Myocardium, Pericardium, and Pulmonary Vasculature Bed
82. Congenital Heart Disease in the Adolescent and Adult
83. Catheter-Based Treatment of Congenital Heart Disease in Adults
84. Cardiomyopathies Induced by Drugs or Toxins
85. Cardiovascular Abnormalities in HIV-Infected Individuals
86. Pericardial Diseases
87. Pulmonary Embolism and Deep Vein Thrombosis
88. Pulmonary Hypertension
89. Sleep-Disordered Breathing and Cardiac Disease

Part X Cardiovascular Disease in Select Populations
90. Cardiovascular Disease in Older Adults
91. Cardiovascular Disease in Women
92. Pregnancy and Heart Disease
93. Heart Disease in Racially and Ethnically Diverse Populations

Part XI Cardiovascular Disease and Disorders of Other Organs
94. Endemic and Pandemic Viral Illnesses and Cardiovascular Disease: Influenza and COVID-19
95. Hemostasis, Thrombosis, Fibrinolysis, and Cardiovascular Disease
96. Endocrine Disorders and Cardiovascular Disease
97. Rheumatic Diseases and the Cardiovascular System
98. Tumors Affecting the Cardiovascular System
99. Psychiatric and Psychosocial Aspects of Cardiovascular Disease
100. Neuromuscular Disorders and Cardiovascular Disease
101. Interface Between Renal Disease and Cardiovascular Illness
102. Cardiovascular Manifestations of Autonomic Disorders

About the Author

Dr. Peter Libby is a cardiovascular medicine specialist at Brigham and Women's Hospital and Mallinckrodt Professor of Medicine at Harvard Medical School (HMS). Receiving his medical degree from the University of California, San Diego School of Medicine, he undertook a cellular physiology research fellowship at HMS. After a residency in internal medicine and a fellowship in cardiovascular disease, he became board certified in both. He is an editor of the leading cardiovascular medicine textbook, and the author of over 500 peer-reviewed publications, 575 reviews, chapters, etc. He has received funding from the American Heart Association (AHA) and National Institutes of Health, plus recognitions on four continents, including the AHA and American College of Cardiology's highest research awards, the Gold Medal of the European Society of Cardiology, the Anitschkow award from the European Atherosclerosis Society, the Ernst Jung Gold Medal for Medicine, and the Earl Benditt award for vascular biology. Dr. Eugene Braunwald, an Elsevier Author, is considered the leading name in cardiology and his research has expanded knowledge and understanding in the areas of congestive heart failure, coronary artery disease, and valvular heart disease. He has authored more than 1400 medical articles and his textbook, Braunwald's Heart Disease, is cited worldwide and recognized as the best book on the subject.

Reviews

"This is the 12th edition of this leading textbook of cardiovascular medicine. The book provides a comprehensive, carefully curated, up-to-date overview of the fundamental pathophysiologic mechanisms in the field of cardiovascular disease." --©Doody’s Review Service, 2022, Luna Khanal, MD (East Tennessee State University Quillen College of Medicine) Doody's Score: 4 Stars!

"The quality and content of this book is unparalleled. This book is an invaluable resource for practicing physicians and all healthcare providers. It is a must-read book for anyone who wants to learn about cardiovascular diseases." --©Doody’s Review Service, 2022, Sai Karthik Kommineni, MBBS (East Tennessee State University Quillen College of Medicine) Doody's Score: 5 Stars!