The search for the most favorable therapeutic ratio ??? at which ablation of cancer is achieved while normal tissues are conserved ??? has been modern radiation oncology??'s equivalent of the quest for the Holy Grail. Our awareness of the late effects of radiation grew during the past century as new modalities were introduced. Heightened normal tissue reactions accompanied the higher rates of cancer ablation achieved by escalation of radiation doses, accelerated fractionated radiotherapy, and aggressive concurrent chemotherapy and radiation regimens. This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. Written by experts in the field, it addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation.
Radiation (and Medical) Biosurveillance: Screening Survivors for Late Effects of Therapy.- Radiation Biodefense: Medical Countermeasures to Radiation Injury: Science and Service in the Public Interest. A Tribute to Robert Kallman.- Radiation Biopathology: Ionizing Radiation and the Endothelium.- Radiation Biomarkers: Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury.- Radiation Biomechanisms: Volume Effects in Radiation Damage to Rat Lung.- Radiation Bioimaging: The Role of Imaging in the Study of Radiation-Induced Normal Tissue Injury.- Radiation Biophysiology: Screening for Cardiovascular Disease in Survivors of Thoracic Radiation.- Radiation Biointervention: Hypoxia Mediated Chronic Normal Tissue Injury: A New Paradigm and Potential. Strategies for Intervention.- Radiation Bioprevention: Prevention and Treatment of Radiation Injuries: The Role of the Renin-Angiotensin System.- Radiation Bioepidemiology: Second Malignancies as a Consequence of Radiation Therapy.- Radiation Bioinformatics: Using Quality of Life Information to Rationally Incorporate Normal Tissue Effects into Treatment Plan Evaluation and Scoring.- Radiation Bioscoring: Cancer-Related Fatigue as a Late Effect: Severity in Relation to Diagnosis, Therapy, and Related Symptoms.- Radiation Biotoxicity Taxonomy: A Normal Tissue TNM Toxicity Taxonomy: Scoring the Adverse Effects of Cancer Treatment.- Radiation Biocontinuum: Follow-Up Care For Cancer Survivors: Needs, Issues, and Strategies.
From the reviews: "This book provides a basic science understanding of the processes behind the side effects of radiation. ... is appropriate for residents, clinicians, radiobiologists, and medical physicists as it addresses the fundamentals necessary for a firm understanding of radiation sequelae. ... The color pictures, graphs, diagrams, and tables beautifully illustrate the main concepts of each chapter. ... Chapters outline the guidelines and models for researchers and clinicians ... . should be in the library of every radiation oncology department." (Ann Pittier, Doody's Review Service, August, 2008)