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Cancer Drug Design and Discovery


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The second edition of this authoritative reference features the latest on the design and development of new anticancer small molecules, including topics such as the identification of molecular targets, cancer genomics, personalized medicine and more.

Table of Contents

Introduction - Stephen Neidle Foreword - Hilary Calvert Part I. Basic Principles and methodology Modern cancer drug discovery: integrating targets, technologies and treatments - Paul Workman and Ian Collins Pharmacogenomics and personalised medicines in cancer treatment - Wei-Peng Yong, Ross Soo and Federico Innocenti Structural biology and anticancer drug design - Puja Pathuri, David Norton, Henriette Willems, Dominic Tisi and Harren Jhoti Part II. Drugs in the laboratory and clinic Temozolomide: from cytotoxic to molecularly-targeted agent - Malcolm Stevens Temozolomide: patents and the perils of invention - Malcolm Stevens A new generation of cell-targeted drugs for cancer treatment - Paola B. Arimondo, Nicolas Guilbaud and Christian Bailly Inhibition of DNA repair as a therapeutic target - Stephany Veuger and Nicola J Curtin Inhibitors of tumour angiogenesis - Adrian L. Harris and Daniele G Generali The Renaissance of CYP17 Inhibitors for the Treatment of Prostate Cancer - Qingzhong Hu and Rolf W. Hartmann Apoptosis in Cancer: Mechanisms, Deregulation and Therapeutic Targeting - Zahid H Siddik Targeting the MDM2-p53 protein-protein interaction: design, discovery and development of novel anticancer agents - Ian R Hardcastle Targeting altered metabolism - emerging cancer therapeutic strategy - Minsuh Seo, Robert Blake Crochet and Yong-Hwan Lee Inhibitors of the Phosphatidylinositol 3-kinase (PI3K) Pathway - William A Denny and Gordon W. Rewcastle Antibody-drug conjugates delivering DNA cytotoxics - John A Hartley Inhibition of telomerase: promise, progress and potential pitfalls - Christopher G. Tomlinson, Scott B. Cohen and Tracy M. Bryan Targeting B-RAF: the discovery and development of B-RAF inhibitors - Phillip A Harris Part III. The reality of cancer drugs in the clinic Failure Modes in Anticancer Drug Discovery and Development - Richard A. Walgren and Christopher. A. Slapak Anticancer drug registration and regulation: current challenges and possible solutions - David Taylor, Erling Donnelly and Silvia Chioato

About the Author

Stephen Neidle, DSc, PhD, ARCS, FRSC, Director of Cancer Research UK Biomolecular Structure Group, Director of the Centre for Cancer Medicines, Professor of Chemical Biology, The School of Pharmacy, University College London, UK


"...offers unique information on the discovery and design of new anticancer agents, covering recent notable successes resulting from the human genome and cancer genomics excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry..."--Anticancer Research 34, 2014 "The second edition of this book walks readers through the myriad cancer drugs and their molecular targets, with a special emphasis on past, present, and future drug design efforts... the book examines both drugs currently in the clinic and those merely on the drawing board...This comprehensive update of the 2008 edition will serve student or experienced cancer researchers well as a reference on anticancer drug development." Rating: 4, March 21, 2014 "Specialists in cancer and pharmaceuticals, most in academic settings, look at basic principles of cancer drugs, methodology, drugs in the clinic, new agents, and the reality of cancer drugs in the clinic...They do include many case studies, and some chapters provide questions for classroom use.", February 2014

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