Table of Contents

Circuitry of Checkpoint Response.- Evasion of G1 Checkpoints in Cancer.- Distinct Pathways Involved in S-Phase Checkpoint Control.- Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response.- Centrosomes in Checkpoint Responses.- Interplay of 14-3-3 Family of Proteins with DNA Damage-Regulated Molecules in Checkpoint Control.- Checkpoint Response and the Aetiology of Cancer.- Chromatin Modifications and Orchestration of Checkpoint Response in Cancer.- DNA Damage Response and the Balance Between Cell Survival and Cell Death.- Dysfunction of the RB Retinoblastoma Gene in Cancer.- G1 Phase Cyclins in Cancer Development and Progression.- The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls.- Targeting Checkpoint Response in Cancer Therapy.- Regulation of p53 Activity and Associated Checkpoint Controls.- The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors.- Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy.- p27Kip1 as a Biomarker and Target for Treatment of Cancer.- Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors.- Chk1 and Chk2 as Checkpoint Targets.- Targeting Cdc25 Phosphatases in Cancer Therapy.

Reviews

From the reviews: “This nicely organized book focuses on cell cycle checkpoint and cancer biology/therapeutics. … The book is written for graduate students, residents, and postdoctoral investigators in basic, translational, or clinical cancer research. The contributing authors are active investigators at the forefront of this field. … This book presents timely, comprehensive reviews of the rapidly progressing field of checkpoint. It should be quite useful for readers who are seeking a solid grasp of updated information in this field.” (Hiroaki Kiyokawa, Doody’s Review Service, March, 2010)