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Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. "This is�a 'must have' book for any serious student of clinical immunology...I heartily recommend this book." Reviewed by: Dr Andy Gennery on behalf of the British Journal of Immunology, December 2013 Depend on authoritative information from leading experts in the field who equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. Focus on the information that's most relevant to your daily practice through a highly clinical focus and an extremely practical organization that expedites access to the answers you need. Stay at the forefront of your field with cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital. Catch a glimpse of the future. "On the Horizon" boxes and discussion of translational research at the end of many chapters summarize especially promising research and development over the next 5 - 10 years. Keep current with the latest knowledge and evidence-based practices. Comprehensive updates throughout include up-to-the-minute information on topics like atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity.Find information quickly thanks to a user-friendly format, featuring new color-coded "Key Concepts", "Clinical Pearls", "Clinical Relevance", and "Therapeutic Principles" boxes that signpost critical information.Access the fully searchable text online at expertconsult.com, along with regular updates, downloadable images, and Board review questions ideal for certification and recertification preparation. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
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Table of Contents

PART 1: Fundamental Principles of the Immune Response1 The human immune response2 Organization of the immune system3 Innate immunity4 Antigen receptor genes, gene products, and co-receptors5 The major histocompatibility complex6 Antigens and antigen processing7 Antigen-presenting cells and antigen presentation8 B-cell development and differentiation9 T-cell development10 Cytokines and cytokine receptors11 Chemokines and chemokine receptors12 Lymphocyte adhesion and trafficking13 T-cell activation and tolerance14 Programmed cell death in lymphocytesPART 2: Host Defense Mechanisms and Inflammation15 Immunoglobulin function16 Regulatory T cells17 Helper T-cell subsets and control of the inflammatory response18 Cytotoxic lymphocyte function and natural killer cells19 Host defenses at mucosal surfaces20 Complement and complement deficiencies21 Phagocytes and phagocyte deficiencies22 Mast cells, basophils and mastocytosis23 Eosinophils and eosinophiliaPART 3: Infection and Immunity24 Immune response to extracellular bacteria25 Immune responses to intracellular bacteria26 Immune responses to spirochetes27 Immune responses to viruses28 I mmune responses to protozoans29 Immune responses to helminthsPART 4: Immunologic Deficiencies30 Evaluation of the immunodeficient patient31 Infections in the immunocompromised host32 Development of the fetal and neonatal immune system33 Aging and the immune system34 Primary antibody deficiencies35 Primary T-cell immunodeficiencies36 Inherited disorders of IFN-?-, IFN-?/?-, and NF-?B-mediated immunity37 HIV infection and acquired immunodeficiency syndrome38 Immunodeficiency due to congenital, metabolic, infectious,surgical, and environmental factorsPART 5: Allergic Diseases39 Pathogenesis of asthma40 Management of the asthmatic patient41 Rhinitis and sinusitus42 Urticaria, angiodema, and anaphylaxis43 Allergic reactions to stinging and biting insects44 Atopic and contact dermatitis45 Food allergy46 Eosinophil-associated gastrointestinal disorders (EGID )47 Allergic disorders of the eye48 Drug hypersensitivity49 Occupational and environmental allergic disordersPART 6: Systemic Immune Diseases50 Mechanisms of autoimmunity51 S ystemic lupus erythematosus52 Rheumatoid arthritis53 Juvenile idiopathic arthritis54 Sjoegren's syndrome55 Systemic sclerosis56 Inflammatory muscle diseases57 Spondyloarthritis58 Small- and medium-vessel primary vasculitis59 Large-vessel vasculitides60 Autoinflammatory fever syndromes61 Antiphospholipid syndromePART 7: Organ Specific Inflammatory Disease62 Immunohematologic disorders63 Bullous diseases of the skin and mucous membranes64 Myasthenia gravis65 Multiple sclerosis66 Autoimmune peripheral neuropathies67 Immunologic renal diseases68 Inflammation and atherothrombosis69 Autoimmune thyroid diseases70 Diabetes and related autoimmune diseases71 Immunologic lung diseases72 Sarcoidosis73 Immunologic ocular disease74 Immunologic disease of the gastrointesinal tract75 Inflammatory hepatobiliary cirrhosisPART 8: Neoplasia and the Immune System76 Lymphoid leukemias77 Lymphomas including Hodgkin lymphoma78 Monoclonal gammopathies79 Tumor immunology and immunotherapyPART 9: Transplantation80 Concepts and challenges in transplantation: rejection,immunosuppression and tolerance81 Challenges and potentials of xenotransplantation82 Hematopoietic stem cell transplantation for malignant diseases83 Stem cell transplantation and immune reconstitutionin immunodeficiency84 Thymic reconstitutionPART 10: Prevention and Therapy of Immunologic Diseases85 Immunoglobulin therapy: replacement and immunomodulation86 Gene transfer therapy of immunologic diseases87 Glucocorticoids88 Nonsteroidal anti-inflammatory drugs89 Antihistamines90 Immunomodulating pharmaceuticals91 Protein kinase antagonists as therapeutic agents for immunologicaland inflammatory disorders92 Vaccines93 Immunotherapy of allergic disease94 Cytokine therapy95 Monoclonal antibodies and fusion proteinsPART 11: Diagnostic Immunology96 Assessment of proteins of the immune system97 Flow cytometry98 Assessment of functional immune responses99 Assessment of neutrophil function100 Assessment of human allergic diseases101 Molecular methodsApendices1 Selected CD molecules and their characteristics2 Laboratory reference values3 Chemokines4 Cytokines

Reviews

-The authors and editors have taken pains to make the text clinician-friendly...The page layout is pleasing to the eye and easy to use.- - JAMA, review of the last edition -This is?a 'must have' book for any serious student of clinical immunology...Certain highlights stand out for me: the use of line diagrams? to supplement histological photographs is excellent- to provide clarity to the features that are being demonstrated...overall, thiw book is very readable and user friendly, despite the size, and I learnt a lot. I heartily recommend this book.- Reviewed by: Dr Andy Gennery on behalf of the British Journal of Immunology, December 2013

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