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Clinical Immunology
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Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. "This is�a 'must have' book for any serious student of clinical immunology...I heartily recommend this book." Reviewed by: Dr Andy Gennery on behalf of the British Journal of Immunology, December 2013 Depend on authoritative information from leading experts in the field who equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. Focus on the information that's most relevant to your daily practice through a highly clinical focus and an extremely practical organization that expedites access to the answers you need. Stay at the forefront of your field with cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital. Catch a glimpse of the future. "On the Horizon" boxes and discussion of translational research at the end of many chapters summarize especially promising research and development over the next 5 - 10 years. Keep current with the latest knowledge and evidence-based practices. Comprehensive updates throughout include up-to-the-minute information on topics like atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity. Find information quickly thanks to a user-friendly format, featuring new color-coded "Key Concepts", "Clinical Pearls", "Clinical Relevance", and "Therapeutic Principles" boxes that signpost critical information. Access the fully searchable text online at expertconsult.com, along with regular updates, downloadable images, and Board review questions ideal for certification and recertification preparation. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
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Table of Contents

PART 1: Fundamental Principles of the Immune Response 1 The human immune response 2 Organization of the immune system 3 Innate immunity 4 Antigen receptor genes, gene products, and co-receptors 5 The major histocompatibility complex 6 Antigens and antigen processing 7 Antigen-presenting cells and antigen presentation 8 B-cell development and differentiation 9 T-cell development 10 Cytokines and cytokine receptors 11 Chemokines and chemokine receptors 12 Lymphocyte adhesion and trafficking 13 T-cell activation and tolerance 14 Programmed cell death in lymphocytes PART 2: Host Defense Mechanisms and Inflammation 15 Immunoglobulin function 16 Regulatory T cells 17 Helper T-cell subsets and control of the inflammatory response 18 Cytotoxic lymphocyte function and natural killer cells 19 Host defenses at mucosal surfaces 20 Complement and complement deficiencies 21 Phagocytes and phagocyte deficiencies 22 Mast cells, basophils and mastocytosis 23 Eosinophils and eosinophilia PART 3: Infection and Immunity 24 Immune response to extracellular bacteria 25 Immune responses to intracellular bacteria 26 Immune responses to spirochetes 27 Immune responses to viruses 28 I mmune responses to protozoans 29 Immune responses to helminths PART 4: Immunologic Deficiencies 30 Evaluation of the immunodeficient patient 31 Infections in the immunocompromised host 32 Development of the fetal and neonatal immune system 33 Aging and the immune system 34 Primary antibody deficiencies 35 Primary T-cell immunodeficiencies 36 Inherited disorders of IFN-?-, IFN-?/?-, and NF-?B-mediated immunity 37 HIV infection and acquired immunodeficiency syndrome 38 Immunodeficiency due to congenital, metabolic, infectious, surgical, and environmental factors PART 5: Allergic Diseases 39 Pathogenesis of asthma 40 Management of the asthmatic patient 41 Rhinitis and sinusitus 42 Urticaria, angiodema, and anaphylaxis 43 Allergic reactions to stinging and biting insects 44 Atopic and contact dermatitis 45 Food allergy 46 Eosinophil-associated gastrointestinal disorders (EGID ) 47 Allergic disorders of the eye 48 Drug hypersensitivity 49 Occupational and environmental allergic disorders PART 6: Systemic Immune Diseases 50 Mechanisms of autoimmunity 51 S ystemic lupus erythematosus 52 Rheumatoid arthritis 53 Juvenile idiopathic arthritis 54 Sj gren's syndrome 55 Systemic sclerosis 56 Inflammatory muscle diseases 57 Spondyloarthritis 58 Small- and medium-vessel primary vasculitis 59 Large-vessel vasculitides 60 Autoinflammatory fever syndromes 61 Antiphospholipid syndrome PART 7: Organ Specific Inflammatory Disease 62 Immunohematologic disorders 63 Bullous diseases of the skin and mucous membranes 64 Myasthenia gravis 65 Multiple sclerosis 66 Autoimmune peripheral neuropathies 67 Immunologic renal diseases 68 Inflammation and atherothrombosis 69 Autoimmune thyroid diseases 70 Diabetes and related autoimmune diseases 71 Immunologic lung diseases 72 Sarcoidosis 73 Immunologic ocular disease 74 Immunologic disease of the gastrointesinal tract 75 Inflammatory hepatobiliary cirrhosis PART 8: Neoplasia and the Immune System 76 Lymphoid leukemias 77 Lymphomas including Hodgkin lymphoma 78 Monoclonal gammopathies 79 Tumor immunology and immunotherapy PART 9: Transplantation 80 Concepts and challenges in transplantation: rejection, immunosuppression and tolerance 81 Challenges and potentials of xenotransplantation 82 Hematopoietic stem cell transplantation for malignant diseases 83 Stem cell transplantation and immune reconstitution in immunodeficiency 84 Thymic reconstitution PART 10: Prevention and Therapy of Immunologic Diseases 85 Immunoglobulin therapy: replacement and immunomodulation 86 Gene transfer therapy of immunologic diseases 87 Glucocorticoids 88 Nonsteroidal anti-inflammatory drugs 89 Antihistamines 90 Immunomodulating pharmaceuticals 91 Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders 92 Vaccines 93 Immunotherapy of allergic disease 94 Cytokine therapy 95 Monoclonal antibodies and fusion proteins PART 11: Diagnostic Immunology 96 Assessment of proteins of the immune system 97 Flow cytometry 98 Assessment of functional immune responses 99 Assessment of neutrophil function 100 Assessment of human allergic diseases 101 Molecular methods Apendices 1 Selected CD molecules and their characteristics 2 Laboratory reference values 3 Chemokines 4 Cytokines

Reviews

"The authors and editors have taken pains to make the text clinician-friendly...The page layout is pleasing to the eye and easy to use." - JAMA, review of the last edition "This is?a 'must have' book for any serious student of clinical immunology...Certain highlights stand out for me: the use of line diagrams? to supplement histological photographs is excellent- to provide clarity to the features that are being demonstrated...overall, thiw book is very readable and user friendly, despite the size, and I learnt a lot. I heartily recommend this book." Reviewed by: Dr Andy Gennery on behalf of the British Journal of Immunology, December 2013

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