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Clinical Laboratory Animal Medicine
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Table of Contents

About the Authors xii Preface xiii About the Companion Website xiv 1 Introduction to Laboratory Animal Medicine 1 Animals Used in Research, Teaching, and Testing 2 Ethical Considerations 8 Organizations 12 Bibliography 17 Further Reading 18 Chapter 1 Review 19 2 Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals 22 Animal Welfare Act and Regulations 22 Public Health Service Policy on Humane Care and Use of Laboratory Animals 28 Other Regulations, Policies, Guidance Documents, and Organizations 31 References 36 Further Reading 37 Chapter 2 Review 37 3 Facility Design, Housing, Equipment, and Management 39 Laboratory Animal Facility Design 39 Common Facility Classifications 46 Housing 50 Facility Equipment 59 Management 66 Bibliography 69 Further Reading 69 Chapter 3 Review 71 4 Mice 74 Genetics 74 Microbiologic Classifications 76 Uses 77 Behavior 77 Anatomic and Physiologic Features 78 Breeding and Reproduction 80 Husbandry 81 Techniques 86 Special Techniques: Transgenic Production Technology 96 Therapeutic Agents 101 Introduction to Diseases of Mice 101 Viral Diseases 107 References 114 Further Reading 119 Chapter 4 Review 122 5 Rats 124 Genetics 124 Microbiologic Classifications 125 Uses 126 Behavior 126 Anatomic and Physiologic Features 127 Breeding and Reproduction 129 Husbandry 130 Techniques 133 Therapeutic Agents 143 Introduction to Diseases of Rats 144 Bibliography 157 Further Reading 162 Chapter 5 Review 162 6 Gerbils 165 Uses 165 Behavior 166 Anatomic and Physiologic Features 166 Breeding and Reproduction 167 Husbandry 168 Techniques 170 Therapeutic Agents 176 Introduction to Diseases of Gerbils 176 Bibliography 181 Further Reading 183 Chapter 6 Review 184 7 Hamsters 185 Uses 185 Behavior 186 Anatomic and Physiologic Features 187 Breeding and Reproduction 189 Husbandry 190 Techniques 192 Therapeutic Agents 198 Introduction to Diseases of Hamsters 198 Bibliography 207 Further Reading 209 Chapter 7 Review 210 8 Guinea Pigs 212 Uses 212 Behavior 213 Anatomic and Physiologic Features 214 Breeding and Reproduction 216 Husbandry 218 Techniques 219 Therapeutic Agents 225 Introduction to Diseases of Guinea Pigs 226 Bibliography 238 Further Reading 240 Chapter 8 Review 242 9 Chinchillas 243 Uses 243 Behavior 244 Anatomic and Physiologic Features 244 Breeding and Reproduction 246 Husbandry 247 Techniques 249 Therapeutic Agents 253 Introduction to Diseases of Chinchillas 255 Bibliography 260 Further Reading 262 Chapter 9 Review 262 10 Zebrafish 264 Uses 264 Behavior 265 Anatomic and Physiologic Features 265 Reproduction and Life Stages 266 Husbandry 268 Techniques 274 Therapeutic Agents 278 Introduction to Diseases of Zebrafish 278 Bibliography 283 Further Reading 284 Chapter 10 Review 285 11 Rabbits 286 Breeds 286 Uses 287 Behavior 288 Anatomic and Physiologic Features 288 Breeding and Reproduction 291 Husbandry 293 Techniques 297 Therapeutic Agents 308 Introduction to Diseases of Rabbits 309 Bibliography 326 Further Reading 329 Chapter 11 Review 331 12 Ferrets 333 Uses 333 Behavior 334 Anatomic and Physiologic Features 334 Breeding and Reproduction 336 Husbandry 337 Techniques 339 Therapeutic Agents 347 Introduction to Diseases of Ferrets 347 Bibliography 365 Further Reading 369 Chapter 12 Review 369 13 Primates 371 Taxonomy 371 Uses 375 Behavior 376 Anatomic and Physiologic Features 377 Breeding and Reproduction 378 Husbandry 380 Techniques 383 Therapeutic Agents 390 Introduction to Diseases of Nonhuman Primates 390 Bibliography 410 Further Reading 413 Chapter 13 Review 416 14 Cattle, Sheep, Goats, and Pigs 417 Uses 417 Behavior 418 Anatomic and Physiologic Features 419 Breeding and Reproduction 419 Husbandry 420 Techniques 424 Therapeutic Agents 428 Introduction to Diseases of Agricultural Animals of Particular Importance to Research 428 Bibliography 434 Further Reading 435 Chapter 14 Review 435 15 Research Variables, Biosecurity, and Colony Health Surveillance 437 Research Variables 437 Biosecurity and Exclusion of Contaminants 445 Animal Colony Health Surveillance 448 Bibliography 455 Further Reading 455 Chapter 15 Review 456 Appendix 1: Normal Values 459 Appendix 2: Comparative Biologic and Reproductive Values by Species 464 Answers to Review Questions 467 Index 474

About the Author

The authors Lesley A. Colby, DVM, MS, DACLAM, is an Associate Professor and Senior Director of Animal Resources and Operations in the Department of Comparative Medicine at the University of Washington in Seattle, Washington, USA. Megan H. Nowland, DVM, DACLAM, is an Associate Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA. Lucy H. Kennedy, DVM, DACLAM, is an Assistant Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.

Reviews

"When a book's title includes the words "An Introduction," one often automatically assumes that it is not an extensive, all-encompassing tome where answers to almost every question can be found. But oh, what an introduction is provided in the fifth edition of Clinical Laboratory Animal Medicine: An Introduction!...I predict this book will be instrumental in training the next generation of laboratory animal scientists, veterinary technicians, and veterinarians." - JAVMA, Mar 15, 2020, Vol.256, No.6

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