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Clinical Research Made Easy
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Table of Contents

Section 1: The Basics The Origins of Evidence-based Medicine Why do We Need Evidence-based Medicine Tips to becoming an Evidence-based Clinician Quality of Evidence-has it Improved? Section 2: Choosing the Right Study Design Levels of Evidence-A Quick Guide Level 1 Evidence-Randomized Controlled Trials Level 2 Evidence-Prospective Cohort Studies Level 3 Evidence-Case-control Studies Level 4 Evidence-Clinical Case Series Level 5 Evidence-Surveys Section 3: Special Designs and Topics The Basics of Systematic Reviews and Meta-analysis The Basics of Economic Evaluation The Basics of a Diagnostic Test Study The Basics of Reliability Quick Guide to Assess Risk of Bias in Randomized Controlled Trials GRADE-Understanding Grades of Healthcare Recommendations Section 4: The Research Protocol First Things First-The Research Proposal Choosing the Outcome-A Primer Common Quality of Life and Health Utility Outcome Tools An Introduction to Sample Size Estimating an Appropriate Sample Size-Advanced Concepts, Formulae and Examples Planning your Analysis-Keep it Simple What are Subgroup Analyses and How Should You Interpret Them? Section 5: Doing Research Study Roles-Who does What? Research Ethics Approval-A must Before any Clinical Trial Why do we Need Patient Consent? Designing a Good Consent Form Collecting Data-It all Begins with a Good Data Form Section 6: Getting the Word Out- Presentation and Publication Creating an Impactful Slide Presentation Writing a Good Clinical Research Paper Making Sense of Reporting Guidelines Submitting a Paper for Publication-A Guide to Success Knowledge Translation 101-Maximizing Impact Glossary Index

About the Author

Mohit Bhandari MD MSc PhD FRCSC Canada Research Chair in Musculoskeletal Trauma and Surgical Outcomes, Professor, Department of Surgery, Associate Member, Department of Health Research Methods, Evidence and Impact, Academic Division Head, Orthopaedic Surgery, McMaster University, Hamilton, USA Parag Kantilal Sancheti FRCS MS DNB MCh Professor and Chairman, Sancheti Institute for Orthopaedics and Rehabilitation, Pune, Maharashtra, India

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