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Clinical Trials in Heart Disease

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Table of Contents

Section I. METHODOLOGY Chapter 1: Contributions of Basic Research, Observational Studies, and Randomized Trials Chapter 2: Methodology of Randomized Trials Chapter 3: Comparative Features of Primordial, Primary and Secondary Prevention Trials Chapter 4: Principles of Data and Safety Monitoring Boards in Randomized Trials Section II. TREATMENT TRIALS A. Treatment of Acute Coronary Ischemia Chapter 5: Aspirin and Thienopyridines Chapter 6: Heparin and Low Molecular Weight Heparin in Acute Coronary Ischemia Chapter 7: Clinical Trials in Thrombolytic Therapy Chapter 8: Clinical Trials of Direct Thrombin Inhibitors Chapter 9: Glycoprotein IIb/IIIa Receptor Inhibitors Chapter 10: Adjunctive Medical Therapy for Acute Myocardial Infarction Chapter 11: Primary, Rescue and Adjunctive Mechanical Intervention in the Setting of Acute Myocardial Infarction Chapter 12: Coronary Artery Bypass Surgery in Acute Coronary Syndromes B. Treatment of Arrhythmias Chapter 13: Drug Therapy for Ventricular Tachycardia and Ventricular Fibrillation Chapter 14: Antiarrhythmic Drug Therapy in Supraventricular Tachycardia Chapter 15: Anticoagulant and Antiplatelet Drug Therapy for Atrial Fibrillation Chapter 16: Clinical Trials in Arrhythmia Ablation Chapter 17: Clinical Trials of Implantable Cardioverter-Defibrillators (ICDs) and Cardiac Resynchronization Therapy/Defibrillation Chapter 18: Clinical Trials in Pacing C. Treatment of Congestive Heart Failure Chapter 19: Drugs Blocking the Renin-Angiotensin-Aldosterone System (RAAS) Chapter 20: Beta-blocker Treatment of Heart Failure Chapter 21: Clinical Trials in Heart Transplantation and Mechanical Cardiac Support for End-Stage Heart Failure Section III. PRIMARY AND SECONDARY PREVENTION TRIALS Chapter 22: Cholesterol Reduction Chapter 23: Blood Pressure Reduction Treatment Trials Chapter 24: Prevention Trials of Smoking Cessation Chapter 25: Physical Activity and Weight Loss Chapter 26: Aspirin, Other Antiplatelet Agents, and Anticoagulant Agents in the Secondary and Primary Prevention of Cardiovascular Disease Chapter 27: Postmenopausal Hormone Replacement Therapy Chapter 28: Antioxidant Vitamins Chapter 29: Dietary Factors Chapter 30: Cardiac Psychology/Behavioral Cardiology Chapter 31: Multiple Risk Factor Intervention Trials Chapter 32: Prevention Strategies: From the Office to the Community and Beyond

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