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Clinical Trials in Heart Disease
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Understanding clinical trials and the resulting outcomes is important to understanding the management of cardiovascular health. This new edition (a companion to Braunwald's Heart Disease) covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice. This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered. This book offers indispensable guidance for clinical decision-making in all patient care settings!
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Table of Contents

Section I. METHODOLOGY Chapter 1: Contributions of Basic Research, Observational Studies, and Randomized Trials Chapter 2: Methodology of Randomized Trials Chapter 3: Comparative Features of Primordial, Primary and Secondary Prevention Trials Chapter 4: Principles of Data and Safety Monitoring Boards in Randomized Trials Section II. TREATMENT TRIALS A. Treatment of Acute Coronary Ischemia Chapter 5: Aspirin and Thienopyridines Chapter 6: Heparin and Low Molecular Weight Heparin in Acute Coronary Ischemia Chapter 7: Clinical Trials in Thrombolytic Therapy Chapter 8: Clinical Trials of Direct Thrombin Inhibitors Chapter 9: Glycoprotein IIb/IIIa Receptor Inhibitors Chapter 10: Adjunctive Medical Therapy for Acute Myocardial Infarction Chapter 11: Primary, Rescue and Adjunctive Mechanical Intervention in the Setting of Acute Myocardial Infarction Chapter 12: Coronary Artery Bypass Surgery in Acute Coronary Syndromes B. Treatment of Arrhythmias Chapter 13: Drug Therapy for Ventricular Tachycardia and Ventricular Fibrillation Chapter 14: Antiarrhythmic Drug Therapy in Supraventricular Tachycardia Chapter 15: Anticoagulant and Antiplatelet Drug Therapy for Atrial Fibrillation Chapter 16: Clinical Trials in Arrhythmia Ablation Chapter 17: Clinical Trials of Implantable Cardioverter-Defibrillators (ICDs) and Cardiac Resynchronization Therapy/Defibrillation Chapter 18: Clinical Trials in Pacing C. Treatment of Congestive Heart Failure Chapter 19: Drugs Blocking the Renin-Angiotensin-Aldosterone System (RAAS) Chapter 20: Beta-blocker Treatment of Heart Failure Chapter 21: Clinical Trials in Heart Transplantation and Mechanical Cardiac Support for End-Stage Heart Failure Section III. PRIMARY AND SECONDARY PREVENTION TRIALS Chapter 22: Cholesterol Reduction Chapter 23: Blood Pressure Reduction Treatment Trials Chapter 24: Prevention Trials of Smoking Cessation Chapter 25: Physical Activity and Weight Loss Chapter 26: Aspirin, Other Antiplatelet Agents, and Anticoagulant Agents in the Secondary and Primary Prevention of Cardiovascular Disease Chapter 27: Postmenopausal Hormone Replacement Therapy Chapter 28: Antioxidant Vitamins Chapter 29: Dietary Factors Chapter 30: Cardiac Psychology/Behavioral Cardiology Chapter 31: Multiple Risk Factor Intervention Trials Chapter 32: Prevention Strategies: From the Office to the Community and Beyond

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