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Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context. It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes the beneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists in chemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.
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Table of Contents

1. Combinatorial synthesis ; 2. Library synthesis on resin beads ; 3. Other solid phases ; 4. Solution phase library synthesis ; 5. Encoded combinatorial synthesis ; 6. Beyond peptide libraries ; 7. Solid phase library chemistry ; 8. Analysis of chemistry and products ; 9. Combinatorial chemistry applications ; Index

About the Author

Dr Nicholas K Terrett, Section Head, Discovery Chemistry, Pfizer Central Research, Pfizer Ltd., Sandwich, Kent CT13 9NJ. Tel: 01304 618451. Fax: 01304 618422. Email: nick_terrett@sandwich.pfizer.com

Reviews

The book is a very useful addition to the area at the undergraduate level, as well as providing a rudimentary introduction for those chemists new to the field. All the basics are covered, ranging from solid supports to linkers to examples of reliable non-peptide solidphase chemistries, as well as the more exotic, with regards to tagging and single bead screening. * Mark Bradley, Chemistry in Britain, March 1999, *

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