Table of Contents

Section I: Engineering consideration in design and scale-up of bioreactors
1. Types of bioreactors and important design considerations
2. Immobilized cells bioreactors (types of immobilization and bioreactors)
3. Engineering aspects for scale-up of bioreactors

Section II: Control systems, optimization and artificial intelligence in industrial bioprocessing
4. Bioprocess monitoring and control systems
5. Modeling and simulation of bioreactor process
6. Online monitoring of process parameters during fermentation
7. Modern techniques for optimizing fermentation process parameters
8. Computational tools (CFD, COMSOL etc) in bioprocessing

Section III: Advanced upstream processing
9. Design and development of fermentation process (including suitability of experimental design: full factorial, central composite design, box behnken, plackett burman etc.)
10. Advances in fermentation processes (Batch, fed-batch and continuous)
11. Media preparation and sterilization techniques 12. Factors influencing microbial growth and its kinetics

Section IV: Advanced downstream processing
13. Sedimentation, filtration and centrifugation
14. Cell disruption and isolation
15. Unit operations (Extraction, purification, lyophilization and spray drying, etc.)

About the Author

Prof. Ashok Pandey is currently Executive Director, Centre for Energy and Environmental Sustainability-India, Lucknow. His major research and technological development interests are industrial and environmental biotechnology and energy biosciences, focusing on biomass to biofuels and chemicals, waste to wealth and energy, etc.

Dr. Ranjna Sirohi is currently working as Research Professor in Korea University, Seoul. She obtained B.Tech. degree in Biochemical Engineering and M.Tech. degree in Agricultural Engineering with specialization in Food Biotechnology Engineering. She has worked as Visiting Researcher at the École Polytechnique Fédérale de Lausanne, Switzerland, as Scientist at Centre for Energy and Environment Sustainability, Lucknow and as Senior Project Associate at CSIR-NEERI, Nagpur. She obtained her Ph.D. degree in Process and Food Engineering from G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand. Her major research interests are in the field of Bioprocess Technology - Food & Food Waste Valorisation-Waste to Wealth – Biofuels. She has 65 publications/communications that include 32 research and review papers, 12 book chapters, 7 popular articles and 14 conference proceedings.

Dr Sirohi has won several awards and honors that include Research Excellent Award in the international conference on New Horizons in Biotechnology, Trivandrum, India (2019), Best Poster award in 8th International Forum on Industrial Bioprocessing (IBA-IFIBiop 2019), Miri; Sarawak, Malaysia (2019) and Research Excellence Award in International Conference on Bio-Innovation for Environmental and Health Sustainable Developments (BEHSD-2018), Lucknow, India (2018). She is the Life member of Indian Society of Agricultural Engineers (ISAE); the Biotech Research Society, India (BRSI); Indian Science Congress Association (ISCA) and Association of Food Scientists & Technologists, India (AFSTI). Prof. Christian Larroche is Director of Polytech Clermont-Ferrand, a graduate school of engineering of University Clermont-Auvergne, France. He is also member of the research laboratory Institut Pascal and of the laboratory of excellence ImobS3 at the same university. He has strong research skills and expertise in the area of applied microbiology and biochemical engineering. He is author of 220 documents, including 114 articles, three patents, 15 book chapters and 24 co-editions of books or journal special issues. He is member of French Society for Process Engineering (SFGP), French Society of Biotechnology and European Federation of Chemical Engineering. He is administrator of IBA-IFIBiop and editor of Bioresource Technology. Mohammad J. Taherzadeh is professor in Biotechnology since 2004 at University of Borås in Sweden. He is also director of Resource Recovery, a research profile with about 50 researchers to convert wastes to energy and value-added products. Prof. Taherzadeh has PhD in Bioscience and MSc and Bsc in Chemical Engineering. He is working on converting wastes and residuals to ethanol, biogas, fish feed and superabsorbents, in which fermentation development using bacteria, yeast and filamentous fungi has a heavy weight. Prof. Taherzadeh has more than 120 publications in scientific peer-reviewed journals, 10 book chapters and two patents about filamentous fungi. Mohammad is the panel chairman of “biotechnology, chemical technology and environmental technology” of Swedish Research Council, and also in the editorial board of Bioresource Technology and BioResources.