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DNA Methylation

The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and function of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.
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Table of Contents

Introduction.- The Almost Forgotten Fifth Nucleotide in DNA: An Introduction.- Pattern Formation.- Replication and Translation of Epigenetic Information.- DNA Methyltransferases. Facts, Clues, Mysteries.- DNA Methylation in Plants.- Determinant of Promoter Activity.- DNA Methylation: De novo Methylation, Long-term Promoter Silencing, Methylation Patterns in the Human Genome, and Consequences of Foreign DNA Insertion.- DNA Methyltransferases.- Establishment and Maintenance of DNA Methylation Patterns in Mammals.- Molecular Enzymology of Mammalian DNA Methyltransferases.- Epigenetic Phenomena.- Familial Hydratidiform Molar Pregnancy: the Germline Imprinting Defect Hypothesis.- Dual Inheritance.- Mutagenesis and Repair.- Mutagenesis at Methylated CpG Sequences.- Cytosine Methylation and DNA Repair.- Subject Index.

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