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Home » Books » Nonfiction » Technology » Engineering » Chemical & Biochemical

DNA Methylation and Cancer Therapy

Medical Intelligence Unit

By Moshe Szyf

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Format: Paperback / softback, 256 pages, 2005 Edition
Other Information: 67 black & white illustrations, 2 colour illustrations
Published In: United States, 28 October 2010
This book provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This unique volume focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Key features of this book include discussions of the following topics: The molecular machinery responsible for DNA methylation and their impact on gene expression and tumorigenesis. The emerging relation between DNA methylation and chromatin modifying proteins. How the relationship between DNA methylation and chromatin modifying proteins might clarify the mechanisms and therapeutic implications of aberrant DNA methylation in cancer. Illustrations of the diagnostic potential of methylation in cancer and novel tools for using methylation profiling of cancers. The therapeutic potential of the DNA methylation machinery and novel attempts to target the DNA methylation enzymes in anticancer therapy. This book will be of interest to a wide audience, including oncologists, researchers and clinicians, and graduate students in the fields of oncology, molecular biology, and cancer therapy, as well as researchers and decision-makers in industry focusing on anticancer drugs and diagnosis.

Table of Contents

Preface ................................................................................................ xiii 1. DNA Methylation: Three Decades in Search of Function ...................... 1 Aharon Razin DNA Methylation in Prokaryotes.......................................................... 1 DNA Methylation in Eukaryotes ........................................................... 2 Methylation and Embryogenesis ............................................................ 2 DNA Methylation and Imprinting ........................................................ 4 DNA Methylation in Gene Silencing .................................................... 4 DNA Methylation and Disease.............................................................. 5 Reflections ............................................................................................. 8 2. Epigenetic Mechanisms of Gene Regulation: Relationships between DNA Methylation, Histone Modification, and Chromatin Structure ..................................................................... 13 Keith D. Robertson The Mammalian DNA Methyltransferases (DNMTs) ......................... 14 Interaction between DNMTs and Other Proteins ............................... 16 DNA Methylation and DNA Replication ............................................ 20 Links between DNA Methylation and Histone Modification .............. 20 DNA Methylation and Histone Methylation ...................................... 21 DNMTs As Transcriptional Corepressors ........................................... 22 DNA Methylation and Chromatin Remodeling .................................. 24 3. DNA Hypo- vs. Hypermethylation in Cancer: Tumor Specificity, Tumor Progression, and Therapeutic Implications .............................. 31 Melanie Ehrlich and GuanchaoJiang Are There Tumor-Specific DNA Hypomethylation Profiles Like the Tumor-Specific DNA Hypermethylation Profiles? .................... 32 Is There a Relationship between Cancer-Associated DNA, Hypomethylation and DNA Hypermethylation? ............................. 34 Is DNA Hypomethylation, Like DNA Hypermethylation, Sometimes Associated with Tumor Progression? .............................. 35 Might There Be Deleterious Consequences of Introducing DNA Hypomethylation in the Genome As a Cancer Therapy? ................. 37 4. DNA Methylation in Urological Cancers ............................................. 42 Wolfgang A. Schulz and Hans-Helge Seifert An Overview of Urological Cancers ..................................................... 42 A Description of DNA Methylation Changes in Urological Malignancies .............................................................. 44 A Global View of DNA Methylation Alterations in Urological Cancers ...................................................................... 47 Causes of Altered DNA Methylation in Urological Cancers ................ 48 Consequences of Altered DNA Methylation in Urological Cancers ....... 50 DNA Methylation in Diagnosis and Therapy of Urological Cancers ...... 51 Szyf MIU Front Matter 9/15/04, 2:29 PM 5 5. DNA Methylation in Colorectal Cancer ............................................... 59 Jeremy R. Jass, Vicki L.J. Whitehall, Joanne Young and Barbara A. Leggett Relevance of Familial Models of Colorectal Cancer to Sporadic Neoplasia ...................................................................... 60 DNA Microsatellite Instability ............................................................ 60 Mechanisms Underlying Microsatellite Instability in Colorectal Cancer .........................

EAN: 9781441934161
ISBN: 1441934162
Publisher: Springer-Verlag New York Inc.
Dimensions: 23.39 x 15.6 x 1.37 centimetres (0.39 kg)
Age Range: 15+ years
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