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DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.
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A comprehensive reference on the role of the epigenome in gene expression and brain function in both normal and diseased states

Table of Contents

Chapter 1. History and Modern View on DNA Modifications in the Brain Chapter 2. Approaches to Detecting DNA Base Modification in the Brain Chapter 3. Active DNA Demethylation in Neurodevelopment Chapter 4. TET and 5hmC in Neurodevelopment and the Adult Brain Chapter 5. Beyond mCG: DNA Methylation in Noncanonical Sequence Context Chapter 6. DNA Modifications and Memory Chapter 7. Measuring CpG Methylation by SMRT Sequencing Chapter 8. Epigenetic Modifications of DNA and Drug Addiction Chapter 9. What Does the Future Hold for the Study of Nucleic Acid Modifications in the Brain?

About the Author

Dr. Timothy Bredy is Associate Professor of Neuroscience in the Ayala School of Biological Sciences at the University of California Irvine and Senior Research Fellow within the Queensland Brain Institute at the University of Queensland.

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