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Home » Books » Science » Medicine » Oncology

DNA and Histone Methylation as Cancer Targets

Cancer Drug Discovery and Development

By Atsushi Kaneda (Edited by), Yu-ichi Tsukada (Edited by)

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Format: Hardcover, 624 pages, 2017 Edition
Other Information: 78 Tables, color; 81 Illustrations, color; 10 Illustrations, black and white; VIII, 624 p. 91 illus., 81 illus. in color.
Published In: Switzerland, 01 October 2017
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Table of Contents

DNA and histone methylation in epigenetics.- The molecular basis of DNA methylation.- The molecular basis of DNA demethylation.- DNA methylation changes in cancer.- Misregulation of DNA methylation regulators in cancer.- The molecular basis of histone methylation.- The molecular basis of histone demethylation.- Misregulation of histone methylation regulators in cancer.- Other histone modifications.- DNA methylation and dysregulation of miRNA in cancer.- Genomic imprinting syndromes and cancer.- DNA and Histone Methylation in Brain Cancer.- DNA and Histone Methylation in Gastric Cancer.- DNA and Histone Methylation in Hematopoietic malignancy.- DNA and Histone methylation in Lung cancer.- DNA and Histone Methylation in Liver Cancer.- DNA and Histone Methylation in Colon Cancer.- DNA and histone methylation in prostate cancer.- DNA and histone modifications in cancer diagnosis.- DNA and histone modifications in cancer therapy.- Future perspective of DNA and histone methylation as cancer targets.

About the Author

Atsushi Kaneda, MD, PhD, is Professor, Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.Yu-ichi Tsukada, PhD, is Professor, Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, Fukuoka, Fukuoka, Japan

EAN: 9783319597843
ISBN: 3319597841
Publisher: Springer International Publishing AG
Dimensions: 23.39 x 15.6 x 3.51 centimetres (1.10 kg)
Age Range: 15+ years
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