Now Australia's Biggest Toy Store

Shop over 1.5 Million Toys in our Huge New Range

The Deeper Genome
By

Rating
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.
Product Details

About the Author

John Parrington is an Associate Professor in Molecular and Cellular Pharmacology at the University of Oxford, and a Tutorial Fellow in Medicine at Worcester College, Oxford. He is the author of Redesigning Life (Oxford University Press, 2016), and has published over 80 peer-reviewed articles in science journals including Nature, Current Biology, Journal of Cell Biology, Journal of Clinical Investigation, The EMBO Journal, Development, Developmental Biology, and Human Reproduction. He has extensive experience writing popular science, having published articles in The Guardian, New Scientist, Chemistry World, and The Biologist. As a British Science Association Media Fellow he worked as a science journalist at The Times for 7 weeks where he published 22 articles. He has also written science reports for the Wellcome Trust, British Council, and Royal Society.

Reviews

This is a brilliant book - a wonderfully entertaining history of molecular biology and the surprises and controversies of a field still very much in flux, from early explorations to the emerging realisation that the human genome may be far more sophisticated than we ever imagined. * John Mattick, Director, Garvan Institute of Medical Research * Overall, this is a faithful, engaging portrait of the twenty-first-century genome * Nature, Nathaniel Comfort * A compelling book that will enrich your knowledge of genetics and its potential. * New York Journal of Books * The Deeper Genome... provides an elegant, accessible account of the profound and unexpected complexities of the human genome, and shows how many ideas developed in the 20th century are being overturned. * New Scientist, Clare Ainsworth * ... a good primer on the subtlety and complexity of the genome, especially the human genome, new facets of which emerge on a regular basis from labs around the world. * The Scientist, Bob Grant * It's a game-changer and a masterpiece for anyone interested in biology * Times Higher Education, Charalambos P Kyriacou * A lively and engaging popuar science book... I recommend it. * Terry Sullivan, International Socialism *

Look for similar items by category
Home » Books » Science » Medicine » Anatomy
People also searched for
How Fishpond Works
Fishpond works with suppliers all over the world to bring you a huge selection of products, really great prices, and delivery included on over 25 million products that we sell. We do our best every day to make Fishpond an awesome place for customers to shop and get what they want — all at the best prices online.
Webmasters, Bloggers & Website Owners
You can earn a 5% commission by selling The Deeper Genome: Why There Is More to the Human Genome Than Meets the Eye on your website. It's easy to get started - we will give you example code. After you're set-up, your website can earn you money while you work, play or even sleep! You should start right now!
Authors / Publishers
Are you the Author or Publisher of a book? Or the manufacturer of one of the millions of products that we sell. You can improve sales and grow your revenue by submitting additional information on this title. The better the information we have about a product, the more we will sell!
Item ships from and is sold by Fishpond World Ltd.
Back to top