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1. Diagnosis and clinical issues 2. Assessing clinical outcomes 3. Basic concepts of neurotransmission in the brain 4. Biochemical basis of depression 5. Pharmacological properties and side-effects of antidepressants: an overview 6. Drug interactions of potential clinical importance 7. Role of serotonin in depression 8. Role of noradenaline in depression 9. Strategies in treatment of resistant affective disorders 10. Extending the clinical use of antidepressants 11. Use of antidepressants in special patient groups