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The Endocannabinoidome


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Breaks down the complexity and highlights the significance of endocannabinoid and cannabinoid receptor research to enable further developments in the discovery of novel lipid mediators that have the ability to contribute to effective therapies

Table of Contents

Introduction Non-endocannabinoid N-acylethanolamines and Monoacylglycerols: Old Molecules, New Targets Omega-3 Polyunsaturated N-acylethanolamines: A Link Between Diet and Cellular Biology Lipoaminoacids: A Combinatoral World of New Lipid Signals Oxidative Metabolites of Endocannabinoids Formed by Cycloocygenase-2 N-acyldopamines and N-acylserotonins: From Synthetic Pharmacological Tools to Endogenous Multi-Target Mediators The Pharmacology of Prostaglandin F2 Ethanolamide and Bimatoprost Reveals a Unique Feed-Back Mechanism on Endocannabinoid Actions Prostamide F2 Biosynthesizing Enzymes Metabolic Enzymes for Endocannabinoids and Endocannabinoid-like Mediators Endocannabinoidomics: "Omics" Approaches Applied to Endocannabinoids and Endocannabinoid-like Mediators Common Receptors for Endocannabinoid-like Mediators and Plant Cannabinoids

About the Author

Dr. Di Marzo has been invited to over 100 International conferences, including a plenary lecture at the Seventh International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Inflammation, in Nashville in October 2001, the Opening Lecture at the School of Neuroscience, held in Catania, July, 2003, a plenary lecture at the Italian Academy of Sciences (Academia Nazionale dei Lincei), in Rome, November 2004, a key note lecture at the 2nd Conference on Non-Mammalian Eicosanoids, Berlin, May 2006, plenary lectures at the 2nd and 3rd Gordon Conference on Cannabinoid function in the brain, Switzerland, 2007 and USA, 2009, a plenary lecture at the XIX National Meeting on Medicinal Chemistry in Verona, September 2008, and a plenary lecture at the 2012 International Conference of PAIN (IASP) held in Milan, August 28. He has been Co-chair at the 4th Gordon Conference on "Cannabinoid function in the brain", Les Diablerets, Switzerland, May 2011. Jenny W. Wang obtained a BS from Peking University in China, a MS from the University of California at Los Angeles (UCLA) in the USA, and a Ph.D. from the University of Aberdeen in the UK. Dr. Wang's professional discipline includes biochemistry, molecular/cellular biology, and pharmacology with experience in anti-cancer, potassium channel, retinoid, and eicosanoid research. She gained extensive knowledge on RNA, DNA, protein, lipid, and assay development while working at City of Hope, California Institute of Technology, Beckman Instruments and Allergan Inc. Dr. Wang is a researcher with a passion in drug discovery. She is currently a Research Investigator on the fatty acid amides program and the team leader on prostamides for hair growth at Allergan, California, USA, where she particularly focuses on eicosanoid research. Her major current therapeutic interests are inflammation and hair growth. In addition to her own research, Dr. Wang enjoys the interaction with academic collaborators and contract research organizations. Dr. Wang is an author of 30 peer-reviewed publications, an inventor on 34 patents (3 granted, 18 published, 13 pending), and has been invited speaker/session chairman at various scientific meetings.

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