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An Evidence-Based Approach to Vitamins and Minerals
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Table of Contents

1 Biotin Function Enzyme Cofactor, Histone Biotinylation Deficiency Signs and Symptoms, Predisposing Conditions, The Adequate Intake Level, Disease Prevention Birth Defects Disease Treatment Diabetes Mellitus, Brittle Fingernails, Hair Loss Sources Bacterial Synthesis Safety Toxicity, Nutrient Interactions, Drug Interactions LPI Recommendation 2 Folic Acid Function One-carbon Metabolism, Nutrient Interactions Deficiency Causes Symptoms The Recommended Dietary Allowance Dietary Folate Equivalents Genetic Variation in Folate Requirements Disease Prevention Pregnancy Complications, Cardiovascular Diseases, Cancer, Alzheimer Disease and Cognitive Impairment Disease Treatment Sources Safety, Toxicity, Drug Interactions LPI Recommendation 3 Niacin Function Oxidation-Reduction (Redox) Reactions, Non-redox Reactions Deficiency Pellagra, Nutrient Interactions, The Recommended Dietary Allowance Disease Prevention Cancer, Type 1 Diabetes Mellitus Disease Treatment High Cholesterol and Cardiovascular Disease, Human Immunodeficiency Virus Sources Safety Toxicity, Drug Interactions LPI Recommendation 4 Pantothenic Acid Function Coenzyme A Acyl-carrier Protein Deficiency The Adequate Intake Level Disease Prevention Disease Treatment Wound Healing, High Cholesterol Sources Intestinal Bacteria Safety Toxicity, Drug Interactions LPI Recommendation 5 Riboflavin Function Oxidation-Reduction (Redox) Reactions, Antioxidant Functions, Nutrient Interactions Deficiency Risk Factors for Riboflavin Deficiency, The Recommended Dietary Allowance Disease Prevention Cataracts Disease Treatment Migraine Headaches Sources Safety Toxicity, Drug Interactions LPI Recommendation 6 Thiamin Function Coenzyme Function Deficiency Causes of Thiamin Deficiency, The Recommended Dietary Allowance Disease Prevention Cataracts Disease Treatment Alzheimer Disease, Congestive Heart Failure, Cancer Sources Safety Toxicity, Drug Interactions LPI Recommendation 7 Vitamin A Function Vision, Regulation of Gene Expression, Immunity, Growth and Development, Red Blood Cell Production, Nutrient Interactions Deficiency Vitamin A Deficiency and Vision, Vitamin A Deficiency and Infectious Disease, The Recommended Dietary Allowance Disease Prevention Cancer Disease Treatment Pharmacological Doses of Retinoids, Diseases of the Skin Sources Retinol Activity Equivalents Safety Toxicity, Safety in Pregnancy, Effects on Bone, Drug Interactions LPI Recommendation 8 Vitamin B6 Function Nervous System Function, Red Blood Cell Formation and Function, Niacin Formation, Hormone Function, Nucleic Acid Synthesis Deficiency The Recommended Dietary Allowance Disease Prevention Cardiovascular Diseases, Immune Function, Cognitive Function, Kidney Stones Disease Treatment Side Effects of Oral Contraceptives, Premenstrual Syndrome, Depression, Nausea and Vomiting in Pregnancy, Carpal Tunnel Syndrome Sources Safety Toxicity, Drug Interactions LPI Recommendation 9 Vitamin B12 Function Cofactor for Methionine Synthase, Cofactor for Methylmalonyl-CoA Mutase Deficiency Causes of Vitamin B12 Deficiency, Other Causes of Vitamin B12 Deficiency, Symptoms of Vitamin B12 Deficiency, The Recommended Dietary Allowance Disease Prevention Cardiovascular Diseases, Cancer, Neural Tube Defects, Alzheimer Disease and Dementia, Depression Sources Safety Toxicity, Drug Interactions LPI Recommendation 10 Vitamin C Function Deficiency Scurvy, The Recommended Dietary Allowance Disease Prevention Cardiovascular Diseases, Cancer, Cataracts, Gout, Lead Toxicity, Role in Immunity Disease Treatment Cardiovascular Diseases, Cancer, Diabetes Mellitus, Common Cold Sources Safety Toxicity, Does Vitamin C Promote Oxidative Damage under Physiological Conditions?, Kidney Stones, Drug Interactions LPI Recommendation 11 Vitamin D Function Activation of Vitamin D, Mechanisms of Action, Calcium Balance, Cell Differentiation, Immunity, Insulin Secretion, Blood Pressure Regulation Deficiency Severe Vitamin D Deficiency, Risk Factors for Vitamin D Deficiency, Assessing Vitamin D Nutritional Status, The Recommended Dietary Allowance Disease Prevention Osteoporosis, Cancer, Autoimmune Diseases, Hypertension Sources Sunlight Safety Toxicity, Drug Interactions LPI Recommendation 12 Vitamin E Function Deficiency The Recommended Dietary Allowance Disease Prevention Cardiovascular Diseases, Cataracts, Immune Function, Cancer Disease Treatment Cardiovascular Diseases, Diabetes Mellitus, Dementia (Impaired Cognitive Function), Cancer Sources Safety Toxicity, Vitamin E Supplementation and All-cause Mortality, Drug Interactions LPI Recommendation 13 Vitamin K Function Coagulation, Bone Mineralization, Cell Growth Deficiency Controversy Surrounding Vitamin K Administration and Newborn Infants, The Adequate Intake Level Disease Prevention Osteoporosis, Vascular Calcification and Cardiovascular Disease Sources Intestinal Bacteria Safety Toxicity, Nutrient Interactions, Drug Interactions LPI Recommendation 14 Calcium Function Structure, Cell Signaling, Cofactor for Enzymes and Proteins, Regulation of Calcium Levels Deficiency Nutrient Interactions, The Recommended Dietary Allowance Disease Prevention Colorectal Cancer, Osteoporosis, Kidney Stones, Pregnancy-induced Hypertension, Lead Toxicity Disease Treatment Hypertension, Premenstrual Syndrome Sources Lead in Calcium Safety Toxicity, Do High Calcium Intakes Increase the Risk of Prostate Cancer?, Drug Interactions, Nutrient Interactions Recent Research Calcium and Weight Loss LPI Recommendation 15 Chromium Function Nutrient Interactions Deficiency The Adequate Intake Level Disease Prevention Impaired Glucose Tolerance and Type 2 Diabetes Mellitus, Cardiovascular Diseases, Health Claims Disease Treatment Type 2 Diabetes Mellitus, Gestational Diabetes Sources Safety Toxicity, Drug Interactions LPI Recommendation 16 Copper Function Energy Production, Connective Tissue Formation, Iron Metabolism, Central Nervous System, Melanin Formation, Antioxidant Functions, Regulation of Gene Expression, Nutrient Interactions Deficiency Individuals at Risk of Deficiency, The Recommended Dietary Allowance Disease Prevention Cardiovascular Diseases, Immune System Function, Osteoporosis Sources Safety Toxicity, Drug Interactions LPI Recommendation 17 Fluoride (Fluorine) Function Nutrient Interactions Deficiency The Adequate Intake Level Disease Prevention Dental Caries, Osteoporosis Disease Treatment Osteoporosis Sources Water Fluoridation, Food and Beverage Sources, Toothpaste Safety Adverse Effects, Drug Interactions LPI Recommendation 18 Iodine Function Deficiency The Effects of Iodine Deficiency by Developmental Stage, Nutrient Interactions, Goitrogens, Individuals at Risk of Iodine Deficiency, The Recommended Dietary Allowance Disease Prevention Radiation-induced Thyroid Cancer Disease Treatment Fibrocystic Breast Condition Sources Safety Acute Toxicity, Iodine Excess, Drug Interactions LPI Recommendation 19 Iron Function Oxygen Transport and Storage, Electron Transport and Energy Metabolism, Antioxidant and Beneficial Prooxidant Functions, Oxygen Sensing, DNA Synthesis, Regulation of Intracellular Iron, Systemic Regulation of Iron Homeostasis, Nutrient Interactions Deficiency Symptoms of Iron Deficiency, Individuals at Increased Risk of Iron Deficiency, The Recommended Dietary Allowance Disease Prevention Impaired Intellectual Development in Children, Lead Toxicity, Pregnancy Complications, Impaired Immune Function Disease Treatment Restless Legs Syndrome Sources Enhancers of Nonheme Iron Absorption, Inhibitors of Nonheme Iron Absorption, Typical Dietary Intake Iron Overload Hereditary Hemochromatosis, Hereditary Anemias Safety Toxicity, Diseases Associated with Iron Excess, Drug Interactions LPI Recommendation 20 Magnesium Function Energy Production, Synthesis of Essential Biomolecules, Structural Roles, Ion Transport across Cell Membranes, Cell Signaling, Cell Migration, Nutrient Interactions Deficiency The Recommended Dietary Allowance Disease Prevention Hypertension, Cardiovascular Diseases, Osteoporosis Disease Treatment Hypertension, Pre-eclampsia-Eclampsia, Cardiovascular Diseases, Diabetes Mellitus, Migraine Headaches, Asthma Sources Safety Toxicity, Drug Interactions LPI Recommendation 21 Manganese Function Antioxidant Function, Metabolism, Bone Development, Wound Healing, Nutrient Interactions Deficiency The Adequate Intake Level Disease Prevention Osteoporosis, Diabetes Mellitus, Seizure Disorders Sources Safety Toxicity, Individuals with Increased Susceptibility to Manganese Toxicity, Drug Interactions, High Levels of Manganese in Marketed for Bone/Joint Health LPI Recommendation 22 Molybdenum Function Nutrient Interactions Deficiency. The Recommended Dietary Allowance Disease Prevention Gastroesophageal Cancer Sources Safety Toxicity, Drug Interactions LPI Recommendation 23 Phosphorus Function Nutrient Interactions Deficiency The Recommended Dietary Allowance Sources Safety Toxicity, Drug Interactions LPI Recommendation 24 Potassium Function Maintenance of Membrane Potential, Cofactor for Enzymes Deficiency Conditions that Increase the Risk of Hypokalemia, The Adequate Intake Level Disease Prevention Stroke, Osteoporosis, Kidney Stones Disease Treatment Hypertension Sources Safety Toxicity (Excess), Adverse Reactions to Potassium, Drug Interactions LPI Recommendation 25 Selenium Function Selenoproteins, Nutrient Interactions Deficiency Individuals at Increased Risk of Selenium Deficiency, Keshan Disease, Kashin-Beck Disease, The Recommended Dietary Allowance Disease Prevention Immune Function, Viral Infection, Cancer, Cardiovascular Diseases, Type 2 Diabetes Mellitus Disease Treatment HIV/AIDS Sources Selenium-enriched Vegetables Safety Toxicity, Drug Interactions LPI Recommendation 26 Sodium Chloride Function Maintenance of Membrane Potential, Nutrient Absorption and Transport, Maintenance of Blood Volume and Blood Pressure Deficiency Hyponatremia, The Adequate Intake Level for Sodium and Sodium Chloride Disease Prevention (Dietary Sodium and Disease) Gastric Cancer, Osteoporosis, Kidney Stones, Hypertension, Cardiovascular Diseases Sources Safety Toxicity, Adverse Effects, Drug Interactions LPI Recommendation 27 Zinc Function Catalytic Role, Structural Role, Regulatory Role, Nutrient Interactions Deficiency Severe Zinc Deficiency, Mild Zinc Deficiency, The Recommended Dietary Allowance Disease Prevention Impaired Growth and Development, Increased Susceptibility to Infectious Disease in Children, Impaired Immune Response in Elderly People, Pregnancy Complications Disease Treatment Common Cold, Age-related Macular Degeneration, Diabetes Mellitus, HIV/AIDS Sources Safety Toxicity, Drug Interactions LPI Recommendation

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Linus Pauling Institute, Oregon State University, Corvallis, OR, USA

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