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Exploring Immunology


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Table of Contents

INTRODUCTION Introduction Immune Responses Infection and Immunity Immunopathology and Immunotherapy Exploring Immunology THE IMMUNE SYSTEM Introduction Host Defence Against Infection Anatomical Basis of Immunity Cellular Basis of Immunity Molecular Basis of Immunity Immune Responses and Disease INFECTION AND IMMUNITY Introduction Pathogens and Infectious Disease Host Defence Against Infection Infection and Immunity in Action Immunity and Vaccines FUNCTIONAL ANATOMY OF THE IMMUNE SYSTEM Introduction Natural Barriers Functional Anatomy of Innate Immunity Functional Anatomy of Adaptive Immunity Development of Blood Cells and Organs of Immunity Stem Cell and Gene Therapy INNATE IMMUNITY Introduction Induction of Innate Immunity "Tissue-Resident Cells" of Innate Immunity Recruited Effectors of Innate Immunity Haematopoiesis and Myeloid Cells Vaccines and Adjuvants T CELL-MEDIATED IMMUNITY Introduction Major Histocompatibility Complex and Antigen Presentation T Lymphocyte Activation Effector and Memory Functions of T Cells in Infection T Cell Development and Selection Adoptive Cell Therapy ANTIBODY-MEDIATED IMMUNITY Introduction Antibody Structure and Function B Cell Responses B Cell Memory, Antibodies and Long-Term Resistance to Re-Infection Cell Differentiation and Selection Therapeutic Antibodies IMMUNITY, DISEASE AND THERAPY Introduction What are the Mechanisms of Tissue Damage Caused by the Immune System? Why Do We Make Harmful Immune Responses to Harmless Antigens? Immunopathology and Therapy in Action Transplantation Immunology Tumour Immunity Conclusions ANSWERS TO THE QUESTIONS FURTHER STUDY QUESTIONS

About the Author

Gordon MacPherson is Reader in Experimental Pathology at the Sir William Dunn School of Pathology, University of Oxford and Tutor in Medicine, Oriel College Oxford. He has taught immunology to medical students for over 30 years in lectures, practical classes and tutorials at both introductory and Honours levels. He teaches all aspects of immunology, and in tutorials also covers microbiology and general pathology. His research interests are in immune regulation, particularly mucosal immunity, and the properties and roles of dendritic cells. He has published many papers (experimental and reviews) and has been an invited speaker at many international conferences Jon Austyn is Professor of Immunobiology in the Nuffield Department of Surgery at the University of Oxford. He has taught extensively in all areas of fundamental immunology over many years, and designed the MSc course in Integrated Immunology at the University of Oxford, which he now co-directs. Jon Austyn has over 25 years research experience of dendritic cell immunobiology, particularly as applied to transplantation, infectious diseases and more recently cancer. He was recently awarded with distinction the Diploma in Learning and Teaching in Higher Education by the University of Oxford.


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