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The Genus Yersinia: Entering the functional genomic era contains 96 timely chapters on different aspects. It summarizes work done both on genome-wide approaches and on detailed microbe-host interactions as well as on genetic, biochemical and chemical characterization of different bacterial components such as lipopolysaccharides, type III secretions systems, porins, virulence effector molecules, gene regulation etc.

Furthermore, modern epidemiological and clinical aspects of Yersiniae are covered in a number of chapters as are the current standings in vaccine production and diagnostics methods. The book format is based on the session division used for the presentations given during the 8th International Symposium on Yersinia. However, this book will also be attractive to researchers and students interested in bacterial pathogenesis since the aspects covered include most of the bacterial strategies so far known to overcome the host defence systems.

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Table of Contents

Part I: Evolution And Genomics. 1. Evolution of Pathogenic Yersinia, Some Lights in the Dark; E. Carniel. 2. DNA Adenine Methylation; V.L. Taylor, et al. 3. Tracing Acquisitions and Losses in Yersinia Genomes; A. Rakin, et al. 4. Subtractive Hybridization Uncovers Novel Pathogenicity-Associated Loci in Yersinia enterocolitica; A.N. Iwobi, et al. 5. Identification of Genes Involved in Yersinia pestis Virulence by Signature-Tagged Mutagenesis; Y. Flashner, et al. 6. Characterization of Two Conjugative Yersinia Plasmids Mobilizing pYV; S. Hertwig, et al. 7. Signature-Tagged Mutagenesis of Yersinia pestis; P.C.F. Oyston, et al. 8. Cobalamin Synthesis in Yersinia enterocolitica 8081; M.B. Prentice, et al. 9. Construction of a Yersinia pestis Microarray; R.A. Stabler, et al. 10. A Conjugal Type IV Transfer System in Yersinia enterocolitica Strains; G. Goelz, et al. 11. Transmission Factors: Yersinia pestis Genes Required to Infect the Flea Vector of Plague; B.J. Hinnebusch. Part II: Pathogenesis And Host Interactions. 12. Rho-GTP Binding Proteins in Yersinia Target Cell Interaction; M. Aepfelbacher, et al. 13. A Technique of Intradermal Injection of Yersinia to Study Y. pestis Physiopathology; F. Guinet, E. Carniel. 14. YopT Is A Cysteine Protease Cleaving Rho Family GTPases; Feng Shao, J.E. Dixon. 15. Structural Studies of Yersinia Adhesin YadA; H. Nummelin, et al. 16. Yersinia pseudotuberculosis Harbors a Type IV Pilus Gene Cluster that Contributes to Pathogenicity; F. Collyn, et al. 17. Salicylanilides are Potent Inhibitors of Type III Secretion in Yersinia; A.M. Kauppi, et al. 18. Mapping of Possible Laminin Binding Sites of Y. pestis Plasminogen Activator (Pla) via Phage Display; O. Benedek, et al. 19. The Fish Pathogen Yersinia ruckeri Possesses a TTS System; D.K. Gunasena, et al. 20. Characterisation of the Type III Secretion Protein YscU in Yersinia pseudotuberculosis; M. Lavander, et al. 21. Mutagenesis Elucidates The Assembly Pathway and Structure of Yersinia pestis F1 Polymer; J.E. Kersley, et al. 22. Characterization of Infections with Wild and Mutant Yersinia pseudotuberculosis Strains in Rabbit Oral Model; H. Najdenski, et al. 23. Identification of Yersinia pestis Pigment Receptor; O.N. Podladchikov, G.G. Dikhanov. 24. Yersinia enterocolitica Biotype 1A: Not as Harmless as You Think; S.M. Tennant, et al. 25. Pestoides F, a Yersinia pestis Strain Lacking Plasminogen Activator, is Virulent by the Aerosol Route; P.L. Worsham, C. Roy. 26. Impact of the Yersinia pseudotuberculosis-Derived Mitogen (YPM) on the Murine Immune System; C. Carnoy, et al. 27. Role of T Cells and Gamma Interferon in Yersinia pseudotuberculosis-Derived Mitogen (YPM)-Induced Toxicity in Mice; H. Kano, et al. 28. Yersinia pestis Pla Has Multiple Virulence-Associated Functions; K. Lahteenaki, et al. 29. Polyclonal B-Cell Activation in Mice

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