Section I: General Principles. Introduction. 1. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination. 2. Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect. 3. Principles of Therapeutics. 4. Principles of Toxicology and Treatment of Poisoning. 5. Gene-Based Therapy. Section II: Drugs Acting at Synaptic and Neuroeffector Junctional Sites. 6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems. 7. Muscarinic Receptor Agonists and Antagonists. 8. Anticholinesterase Agents. 9. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia. 10. Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists. 11. 5-Hydroxtryptamine (Serotonin) Receptor Agonists and Antagonists. Section III: Drugs Acting on the Central Nervous System. 12. Neurotransmission and the Central Nervous System. 13. History and Principles of Anesthesiology. 14. General Anesthetics. 15. Local Anesthetics. 16. Therapeutic Gases. 17. Hypnotics and Sedatives. 18. Ethanol. 19. Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety. 20. Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania. 21. Drugs Effective in the Therapy of the Epilepsies. 22. Treatment of the Central Nervous System Degenerative Disorders. 23. Opioid Analgesics and Antagonists. 24. Drug Addiction and Drug Abuse. Section IV: Autacoids; Drug Therapy of Inflammation. 25. Histamine, Bradykinin, and Their Antagonists. 26. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor. 27. Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout. 28. Drugs Used in the Treatment of Asthma. Section V: Drugs Affecting Renal and Cardiovascular Function. 29. Diuretics. 30. Vasopressin and Other Agents Affecting the Renal Conservation of Water. 31. Renin and Angiotensin. 32. Drugs Used for the Treatment of Myocardial Ischemia. 33. Antihypertensive Agents and the Drug Therapy of Hypertension. 34. Pharmacological Treatment of Heart Failure. 35. Antiarrhythmic Drugs. 36. Drugs Used in the Treatment of Hyperlipoproteinemias. Section VI: Drugs Affecting Gastrointestinal Function. 37. A. Treatment of Acid-Peptic Diseases. 38. B. Prokinetic and Anti-Emetic Drugs. 39. C. Gastrointestinal Motility & Luminal Flux. Section VII: Chemotherapy of Microbial Diseases. 40. Drugs Used in the Chemotherapy of Protozoal Infections: Malaria. 41. Drugs Used in the Chemotherapy of Protozoal Infections: Trypanosomiasis, Leishmaniasis, Amebiasis, Giardiasis, Trichomoniasis, and Other Protozoal Infections. 42. Drugs Used in the Chemotherapy of Helminthiasis. Section VIII: Chemotherapy of Microbial Diseases. 43. Antimicrobial Agents: General Considerations. 44. Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections. 45. Antimicrobial Agents: Penicillins, Cephalosporins, and Other B-Lactam Antibiotics. 46. Antimicrobial Agents: The Aminoglycosides. 47. Antimicrobial Agents: Tetracyclines, Chloramphenicol, Erythromycin, and Miscellaneous Antibacterial Agents. 48. Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis and Leprosy. 49. Antimicrobial Agents: Antifungal Agents. 50. Antimicrobial Agents: Antiviral Agents. 51. Antimicrobial Agents: Antiretroviral Agents. Section IX: Chemotherapy of Neoplastic Diseases. 52. Antineoplastic Agents. Section X: Drugs Used for Immunomodulation. 53. Immunomodulators: Immunosuppressive Agents and Immunostimulants. Section XI: Drugs Acting on the Blood and the Blood-Forming Organs. 54. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. 55. Antiocagulant, Thrombolytic, and Antiplatelet Drugs. Section XII: Hormones and Hormone Antagonists. 56. Adenohypophyseal Hormones and Their Hypothalamic Releasing Factors. 57. Thyroid and Antithyroid Drugs. 58. Estrogens and Progestins. 59. Androgens. 60. Adrenocorticotropic Hormone;Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones. 61. Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas. 62. Agents Affecting Calcification and Bone Turnover: Clacium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds. Section XIII: The Vitamins. 63. Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid. 64. Fat-Soluble Vitamins: Vitamins A, K, and E. Section XIV: Dermatology. 65. Dermatological Pharmacology. Section XV: Opthalmology. 66. Ocular Pharmacology. Section XVI: Toxicology. 67. Heavy Metals and Heavy-Metal Antagonists. 68. Nonmetallic Environmental Toxicants: Air Pollutants, Solvents, Vapors, and Pesticides. Appendices: I. Principles of Prescription Order Writing and Patient Compliance Instructions. II. Design and Optimization of Dosage Regimens; Pharmacokinetic Data.
Joel G. Hardman, Ph.D. is Emeritus Professor, Vanderbil University School of Medicine, Nashvill, TN. Lee Limbird, Ph.D., is Professor and Chairman, Department of Pharmacy, Vanderbilt University School of Medicine.
"It's an honor to review the tenth edition of this classic text. The eighth edition helped me learn pharmacology 10 years ago, and ninth edition has helped me teach pharmacology in recent years." "Numerous tables help to classify and organize this massive body of knowledge." Journal of American Medical Association 20021024 "For 60 years (first published in 1941) Goodman & Gilman has been a widely used pharmacology text." "The tenth edition is a must-have book for faculty abd graduate students. It will challenge undergraduate students, but is recommended as a reference/text with which they should be familiar and comfortable using." American Journal of Pharmaceutical Education 20020423 " The tenth edition is a must-have book for faculty and graduate students. It will challenge undergraduate students, but is recommended as a reference/text with which they should be familiar and comfortable using." American Journal of Pharmaceutical Education 20020401 "There are other reference and textbook options for pharmacologic information, but Goodman & Gilman's The Pharmacological Basis of Therapeutics remains the gold standard for the most comnprehensive explanantions of clinical pharmacology. It is an invaluable reference and is highly recommended as a guide for all healthcare professionals." The Journal of Pharmacy Technology 20020301 "As the most comprehensive of all the pharmacology textbooks, this edition continues the excellent tradition of this icon in pharmacology. It is the "gold standard" of pharmacology texts, and is often affectionately referred to by pharmacologists as the "bible." "4 Stars" Doody's 20011001