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Group Sequential Methods with Applications to Clinical Trials
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Table of Contents

Glossary. Introduction. Two-Sided Tests: Introduction. Two-Sided Tests: General Applications. One-Sided Tests. Two-Sided Tests with Early Stopping Under the Null Hypothesis. Equivalence Tests. Flexible Monitoring: The Error Spending Approach. Analysis Following a Sequential Test. Repeated Confidence Intervals. Stochastic Curtailment. General Group Sequential Distribution Theory. Binary Data. Survival Data. Internal Pilots Studies: Sample Size Re-Estimation. Multiple Endpoints. Multi-Armed Trials. Adaptive Treatment Assignment. Bayesian Approaches. Numerical Computations for Group Sequential Tests. References

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"This book represents a comprehensive presentation of group sequential methods. Written by active researchers in this area, it provides an ideal source for those wishing an introduction to the area and for those who desire a clear outline of specific topics or methods. It should quickly become a standard reference both for those wishing to apply the methods and for researchers in the area…The extent of coverage of various topics broadly reflects current usage…the discussion of each topic appears to be well balanced…All in all, this is a very welcome book."
- Short Book Reviews of the ISI

"The statistical methodology for sequential trials is complicated. This book provides an excellent presentation of it. It succeeds as both a training text and as a reference source. I liked the progression of the book…any statistician involved in designing or analysing sequential trials should have a copy."
--Tim Auton, Protherics, Macclesfield

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