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Holland-Frei Cancer Medicine 8
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PART I: CARDINAL MANIFESTATIONS OF CANCER1: Cardinal Manifestations of Cancer James F. Holland, Emil Frei, III, Waun Ki Hong, Donald Kufe, Robert Bast, William Hait, Raphael Pollock, Ralph WeichselbaumPART II: SCIENTIFIC FOUNDATIONS OF CANCERSECTION 1: CANCER BIOLOGY2: Molecular Biology, Genomics, and Proteomic, and Mouse Models of Human Cancer Kornelia Polyak, Matthew Meyerson, William Hahn, David Tuveson
3: Cell Proliferation and Differentiation Michael Andreeff, David W. Goodrich, H. Phillip Koeffler
4: Apoptosis and Cancer John Reed
5: Growth Factors and Signal Transduction in Cancer Stuart A. Aaronson, Luca Grumolato
6: Oncogenes Marco A. Pierotti, Milo Frattini, Gabriella Sozzi, Carlo M. Croce
7: Tumor Supressor Genes Gen-Ho Park, Bert Vogelstein, David Cosgrove
8: Genomic Alterations and Chromosomal Abberations in Human Cancer Jeff Trent, Kevin M. Brown, Jonathan J. Keats, Aleksandar Sekulic, Cheryl L. Willman
9: Biochemistry of Cancer Raymond W. Ruddon, Donald W. Kufe
10: Invasion and Metastases Elise C. Kohn
11: Tumor Angiogenesis John Heymach, Judah Folkman, Raghu Kalluri
12: Epigenetics (to include Novel Treatment) Steve BaylinSECTION 2: CANCER IMMUNOLOGY13: Cancer Immunotherapy Karl S Peggs, Sergio A Quezada, Padmanee Sharma, James P AllisonSECTION 3: CANCER ETIOLOGY14: Genetic Predisposition to Cancer Henry T. Lynch, Vadana Gupta, Marcia S. Brose
15: Chemical Carcinogenesis Ainsley Weston, Curtis C. Harris
16: Hormones and the Etiology of CancerLeslie Bernstein, C. Leigh Pearce, Iona Cheng, Katherine DeLellis Henderson
17: Ionizing Radiation David J. Grdina
18: Ultraviolet Radiation CarcinogenesisJames E. Cleaver, David L. Mitchell
19: Inflammation, Trauma and Physical Agents in Cancer Debbie Laskin
20: RNA Tumor Viruses, Robert Gallo, Marvin S. Reitz
21: Herpesviruses Jeffrey I. Cohen
22: Papillomaviruses and Cervical Neoplasia Christopher P. Crum, Catherine McLachlin
23: Hepatitis Viruses Max W. Sung, Swan N. Thung
24: Parasites Piero MustacchiSECTION 4: TRANSLATIONAL CANCER MEDICINE25: Molecular Imaging Juri Gerlovani
26: Molecular Diagnostics in Cancer Bryan T. Hennessy, Robert C. Bast, Jr., Gordon B. Mills
27: Personalized Medicine in Oncology Drug Development William N. Hait, Nicolas Dracopoli, Steve Heller, Chris H. Takimoto
28: Genomic and Systems Biology Joseph W. Gray
29: Cancer Nanotechnology Mauro FerrariSECTION 5: CANCER EPIDEMIOLOGY, PREVENTION and SCREENING30: Cancer Epidemiology Michael J. Thun
31: Prevention of Tobacco-Related Products Steve Hecht, Dorothy Hatsukami
32: Nutrition in the Etiology and Prevention of Cancer Steven K. Clinton
33: Chemoprevention of Cancer Scott M. Lippman, Waun Ki Hong
34: Cancer Screening and Early Detection Robert A. Smith, Stephen W. Duffy, Otis W. BrawleySECTION 6: CLINICAL TRIALS AND OUTCOMES ASSESSMENT35: Statistical Innovations in Cancer Research Don Berry
36: Outcomes Assessment James A. TalcottPART III: PRINCIPLES OF CANCER DIAGNOSISSECTION 7: CANCER PATHOLOGY37: Principles of Cancer Pathology Stan HamiltonSECTION 8: IMAGING38: Principles of Imaging Edward F. Patz, Jr.
39: Interventional Radiology for the Cancer Patient Michael Wallace, Rony AvritscherPART IV: PRINCIPLES OF THERAPEUTIC MODALITIESSECTION 9: SURGICAL ONCOLOGY40: Principles of Surgical Oncology Raphael E. Pollock, Michael A. Choti, Donald L. MortonSECTION 10: RADIATION ONCOLOGY41: Principles of Radiation Oncology Joseph K. Salama, Mark W. Dewhirst, Ralph R. WeichselbaumSECTION 11: MEDICAL ONCOLOGY42: Principles of Medical Oncology William N. Hait, MD, ,PhD James F. Holland, MD, ScD (hc) Emil Frei III, MD Donald W. Kufe, MD Robert C. Bast Jr, MD Waun Ki Hong, MDSECTION 12: CHEMOTHERAPY43: Cytokinetics Larry Norton, Theresa Ann Gilewski
44: Principles of Dose, Schedule, and Combination Chemotherapy Joseph P. Eder, William Hait
45: Preclinical and Early Clinical Development of New Anticancer Agents Daniel D. Von Hoff, Axel Hanuske
46: Pharmacology William Plunkett, Mark Ratain
47: Drug Resistance and Its Clinical Circumvention Jeffrey Moscow, Erasmus Schneider, Branimir I. Sikic, Charles S. Morrow, Kenneth H. CowanSECTION 13: CHEMOTHERAPEUTIC AGENTS48: Folate Antagonists Joseph R. Bertino, Barton A. Kamen, Peter D. Cole
49: Pyrimidine and Purine Antimetabolites Giuseppe Pizzorno, Sunil Sharma, Yung-Chi Cheng
50: Alkylating Agents and Platinum Antitumor Compounds Michael Colvin
51: Drugs that Target DNA Topoisomerases William N. Hait, Eric H. Rubin
52: Microtubule-Targeting Natural Products Eric Rowinsky SECTION 14: BIOTHERAPEUTICS53: InterferonsErnest C. Borden
54: Cytokines and Hematopoietic Growth FactorsSuhendan Ekmekcioglu, Razelle Kurzrock, Elizabeth A. Grimm
55: Monoclonal Serotherapy Robert C. Bast, Michael R. Zalutskym, Arthur E. Frankel, Robert J. Kreitman
56: Vaccines and Immunostimulants Jeff Schlom, James L. Gulley, Philip M. Arlen, James W. Hodge SECTION 15: ENDOCRINE THERAPY57: Estrogens, Antiestrogens and Aromatase Inhibitors Aman U. Buzdar, Shaheenah Dawood, Harold A. Harvey, V. Craig Jordan
58: Androgen Deprivation Strategies In The Treatment Of Advanced Prostate Cancer Samuel R. Denmeade SECTION 16: GENE THERAPY59: Cancer Gene Therapy Sunil J. Advani, Ralph R. Weichselbaum, Donald W. KufeSECTION 17: BONE MARROW TRANSPLANTATION60: Hematopoietic Cell Transplantation Roy Jones, Elizabeth Shpall, Richard Champlin PART V: PRINCIPLES OF MULTIDISCIPLINARY MANAGEMENTSECTION 18: PSYCHO-ONCOLOGY61: Principles of Psycho-Oncology Jimmie C. Holland SECTION 19: CANCER REHABILITATION MEDICINE62: Principles of Cancer Rehabilitation Medicine Kristjan T. Ragnarsson SECTION 20: MULTIDISCIPLINARY MANAGEMENT63: Multidisciplinary Management James F. Holland, Emil Frei III, III, Waun Ki Hong, Donald W. Kufe, Robert C. Bast Jr, Raphael E. Pollock, Ralph R. Weichselbaum, William N. Hait
64: Pregnancy and Cancer Jennifer K. Litton
65: Cancer and Aging Arti Hurria, Hyman B. Muss, Harvey J. Cohen
66: The Role of Integrative Oncology in Cancer Care Lorenzo Cohen, Nancy Russell, Kay Garcia, Moshe FrenkelSECTION 21: PAIN AND PALLIATION67: Palliative Care Diane Meier, Cardinale B. Smith, Gabrielle R. Goldberg
68: Management of Cancer Pain Natalie Moryl, Alan CarverSECTION 22: CENTRAL NERVOUS SYSTEM69: Primary Neoplasms of the Central Nervous System in Adults Lisa M. DeAngelis
70: Brain Metastases Lisa M. DeAngelisSECTION 23: THE EYE71: Neoplasms of the Eye Amy C. Schefler, David H. Abramsom, Ira J. Dunkel, Beryl McCormickSECTION 24: ENDOCRINE GLANDS72: Neoplasms of the Endocrine Glands: Pituitary Neoplasms Kalman D. Post
73: Neoplasms of the Thyroid Steven I. Sherman
74: Neoplasms of the Adrenal Cortex David E. Schteingart
75: Neuroendocrine System and Gastroentero-pancreatic Endocrine System Evan VosburghSECTION 25: HEAD AND NECK76: Neoplasms of the Head and Neck Michael E. Kupferman, Erich M. Sturgis, David L. Schwartz, Adam Garden, Merrill S. KiesSECTION 26: THE THORAX77: Cancer of the Lung Charles Lu, Amir Onn, Ara A. Vaporciyan, Joe Y. Chang, Bonnie S. Glisson, Ritsuko Komaki, Ignacio I. Wistuba, Jack A. Roth, Roy S. Herbst
78: Malignant Mesothelioma Harvey I. Pass, Michele Carbone, Hedy Kindler
79: Thymomas and Thymic Tumors A. Philippe Chahinian
80: Tumors of the Heart and Great Vessels Sarina van der Zee, A. Philippe Chahinian, Valentin Fuster
81: Primary Germ Cell Tumors of the Thorax Anthony F. Greco, John D. HainsworthSECTION 27: GASTROINTESTINAL TRACT82: Neoplasms of the Esophagus Stephen G. Swisher, David C. Rice, Jaffer A. Ajani, Ritsuko K. Komaki, Mark K. Ferguson
83: Carcinoma of the Stomach Paul Mansfield, James Yao, Christopher Crane, Takeshi Sano
84A: Treatment of Liver Metastases Nancy E. Kemeny, Micheal D'Angelica
84B: Kemeny Treatment of Liver Metastases Max W. Sung, Swan N. Thung
85: Gallbladder and Bile Duct Cancer Ahmed O. Kaseb, Steven A. Curley, Melanie Thomas
86: Neoplasms of the Exocrine Pancreas Robert A. Wolff, Christopher H. Crane, Donghui Li, Douglas B. Evans
87: Neoplasms of the Small Intestine, Vermiform Appendix, Peritoneum and Carcinoma of the Colon and Rectum James C. Padussis, Georgia M. Beasley, Nicole McMahon, Douglas S. Tyler, Kirk Ludwig
88: Neoplasms of the Anus Bruce MinskySECTION 28: GENITOURINARY TRACT89: Renal Cell Carcinoma Derek Raghavan, Brian I. Rini, Daniel Y.C. Heng, Ming Zhou, Andrew Novick
90: Tumors Of The Renal Pelvis And Ureter Derek Raghavan, Ali-Reza Golshayan, Inderbir Gill, Cristina Magi-Galluzzi
91: Bladder Cancer Derek Raghavan,John Stein, Richard Cote, J. Stephen Jones
92: Neoplasms of the Prostate Christopher Logothetis
93: Tumors of the Penis and Urethra Donald F. Lynch
94: Testis Cancer Christian Kollmansberger, Siamak Daneshmand, Eric Hansen, Christopher L. Corless, Bruce J. Roth, Craig R. NicholsSECTION 29: FEMALE REPRODUCTIVE ORGANS95: Neoplasms of the Vulva and Vagina Jacob Rotmensch
96: Neoplasms of the Cervix Anuja Jhingran
97: Endometrial Cancer Carmel J. Cohen, Jamal Rahaman
98: Neoplasms of the Fallopian Tube Carmel J. Cohen, Jamal Rahaman
99: Ovarian Cancer Jonathan S. Berek, Robert Bast, Michael L. Friedlander
100: Molar Pregnancy and Gestational Trophoblastic Neoplasia Ross S. Berkowitz, Dona ld Goldstein
101: Gynecologic Sarcomas Carmel J. Cohen, Jamal RahamanSECTION 30: THE BREAST102: Neoplasms of the Breast Gabriel N. Hortobagyi, Laura Esserman, Thomas A. BuchholzSECTION 31: THE SKIN103: Melanoma Patrick Hwu, Jeff Gershenwald, Boris Bastian
104: Other Skin Cancers Arthur Sober, Victor A. NeelSECTION 32: BONE AND SOFT TISSUE105: Bone Tumors Tim Damron
106: Soft Tissue Sarcomas Peter Pisters , Brian O'Sullivan, Robert G. MakiSECTION 33: HEMATOPOIETIC SYSTEM107: The Myelodyplastic Syndrome Lewis R. Silverman
108: Acute Myeloid Leukemia and Other Mast Cell Neoplasms Charles A. Schiffer, Richard M. Stone
109: Chronic Myeloid Leukemia Magop M. Kantarjian, Jorge Cortes
110: Acute Lymphocytic Leukemia Stefan Faderl, Ching-Hon Pui, Susan O'Brien, Hagop M. Kantarjian
111: Chronic Lymphocytic Leukemia Kanti Rai, Matthew Kaufman
112: Hodgkin Disease James O'Armitage, Peter M. Mauch, Lawrence Weiss
113: Non-Hodgkin Lymphoma Arnold S. Freedman
114: Mycosis Fungoides and the Sezary Syndrome Richard T. Hoppe, Youn H. Kim, Ranjana Advani
115: Plasma Cell Tumors Kenneth C. Anderson, Teru Hideshima, Noopur Raje
116: Myeloproliferative Neoplasms: Essential Thrombocythemia, Primary Myelofibrosis and Polycythemia Vera Ayalew Tefferi SECTION 34: NEOPLASMS IN AIDS117: Neoplasms in Acquired Immunodeficiency Syndrome David T. Scadden, Jeremy S. AbramsonSECTION 35: UNKNOWN PRIMARY SITE118: Neoplasms of Unknown Primary Site John D. Hainsworth, F. Anthony GrecoSECTION 36: PEDIATRIC ONCOLOGY119: Principles of Pediatric Oncology Maura O'Leary, Greg Reaman SECTION 37: COMPLICATIONS OF CANCER AND THEIR TREATMENT120: Cancer Anorexia and Cachexia Takao Ohnuma
121: Antiemetic Therapy David Ettinger, Aditya Bardia
122: Neurologic Complications Lisa M. DeAngelis
123: Dermatologic Complications of Cancer Chemotherapy Cindy Berthelot, Joy H. Kunishige, Narin Apisarnthanarax, Madeleine M. Duvic
124: Skeletal Complications Samuel Kenan, Jeff Mechanick, Michael Via
125: Hematologic Complications and Blood Bank Support Kenneth C. Anderson, Richard M. Kaufman
126: Coagulopathic Complications of Cancer Patients Jacob H. Rand, Maria DeSancho
127: Urologic Complications Christopher J. Logothetis, Diana M. Hey
128: Cardiac Complications Michael S. Ewer, Steven M. Ewer, Thomas Suter
129: Respiratory Complications Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez, Rodolfo C. Morice, Elizabeth L. Travis,
Lara Bashoura, Amar Safdar, Scott E. Evans, Roberto Adachi, Saadia A. Faiz, Diwakar D. Balachandran, Joseph L. Nates, S. Egbert Pravinkumar, Burton F. Dickey
130: Gastrointestinal and Hepatic Complications in Cancer Patients Robert Bresalier, Marta L. Davila
131: Oral Complications of Cancer and Their Treatment Stephen T. Sonis
132: Gonadal Complications Catherine E. Klein, Peter Kabos
133: Endocrine Complications and Paraneoplastic Syndromes Robert F. Gagel, Sai-Ching, Jim Yeung
134: Treatment -Related Secondary Cancers Susan R. Rheingold, Alfred I. Neugut, Thomas Uldrick, Anna T. MeadowsSECTION 38: INFECTION IN THE CANCER PATIENT135: Infections in Patients with Cancer Kenneth V.I. Rolston, Gerald P. BodeySECTION 39: ONCOLOGIC EMERGENCIES136: Oncologic Emergencies S. Jim Yeung, Carmen EscalanteSECTION 40: ONCOLOGY AND INFORMATICS137: Oncology Informatics Edward P. Ambinder

About the Author

Raphael E. Pollock, MD, PhD Head, Division of Surgery Professor and Chairman Department of Surgical Oncology Senator A.M. Aiken, Jr. Distinguished Chair The University of Texas M. D. Anderson Cancer Center Houston, Texas

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