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Section I History and Terminology Brief History of Hormesis and Its Terminology Edward J. Calabrese Pre- and Postconditioning Hormesis F.A.C. Wiegant Section II Evidence for Hormesis in Human Beings Exercise and Hormesis: Shaping the Dose-Response Curve Zsolt Radak Nutritional Components: How They Enhance the Ability to Adapt Antje R. Weseler and Aalt Bast Periodic Fasting and Hormesis Yan Y. Lam and Eric Ravussin Iron, Metabolic Syndrome, and Hormesis Kupper A. Wintergerst and Lu Cai Radiation Exposure Alexander Vaiserman Thermal Hydrotherapy as Adaptive Stress Response: Hormetic Significance, Mechanisms, and Therapeutic Implications G. Scapagnini, S. Davinelli, N.A. Fortunati, D. Zella, and M. Vitale Cardiac Ischemic Preconditioning and the Ischemia/Reperfusion Injury Andreas Simm and Rudiger Horstkorte Cerebral Ischemia Yannick Bejot and Philippe Garnier Optimal Stress, Psychological Resilience, and the Sandpile Model Martha Stark Section III Molecular Mechanisms of Hormesis Molecular Stress Response Pathways as the Basis of Hormesis Dino Demirovic, Irene Martinez de Toda, and Suresh I.S. Rattan Inflammatory Pathways Salvatore Chirumbolo Oxidative Stress Response Pathways: Role of Redox Signaling in Hormesis Li Li Ji Section IV Hormesis in Risk Assessment Relating Hormesis to Ethics and Policy: Conceptual Issues and Scientific Uncertainty George R. Hoffmann Hormesis and Risk Assessment Edward J. Calabrese
Suresh I.S. Rattan, PhD, DSc, is an internationally renowned biogerontologist at the Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark. He is one of the pioneers for the testing and application of hormesis in aging research and interventions. His research expertise includes elucidating the molecular mechanisms of human cellular aging. Dr. Rattan is the discoverer of the aging-modulatory effects of kinetin and zeatin, which are now used in several skin care products. He is the editor-in-chief of the journal Biogerontology. He has published numerous original research papers and reviews, and is the author of popular science books for children in several languages. Eric Le Bourg, PhD, DSc, is an internationally renowned biogerontologist at the French National Center for Scientific Research (CNRS), Universite Paul Sabatier, Toulouse, France. He is well known for his studies on the effects of mild stress in Drosophila but is also working on learning, behavior, and demography matters. He has published numerous papers and has written several books on aging in French for the lay public and academics on the biology, demographic, and social matters. Both editors have previously collaborated and edited the book Mild Stress and Healthy Aging (Springer 2008) and brought out two special issues of the international peer-reviewed journals Biogerontology (2006) and Dose Response (2010).