List of Principal Authors. Section I: Aetiopathogenesis. 1. Susceptibility Genes for IBD; D. van Heel, et al. 2. Interleukin-1 Beta Gene Polymorphisms as Genetic Markers in Perforating and Non-Perforating Crohn's Disease; A. Nemetz, et al. 3. Genetic Determination and Susceptibility: Future Aspects; R.H. Duerr. 4. Interactions Between Enteric Bacteria and the Immune System Which Determine Mucosal Homeostasis vs. Chronic Intestinal Inflammation: Lessons from Rodent Models; R.B. Sartor, C. Veltkamp. 5. Gut Flora: Future Implications; R. Duchmann. 6. Response and Non-Response in the Mucosal Immune System; W. Strober, et al. 7. Immunotherapeutic Approaches in Inflammatory Bowel Diseases; M.F. Neurath, et al. 8. Intestinal Epithelial Barrier Dysfunction; S.V. Sitaraman, et al. 9. IL-10 Inhibits NF-kB by Distinct Mechanisms; A.J.G. Schottelius, et al. 10. Future Ways to Study Epithelial Cell Functions; G. Rogler. 11. Regulation of Intestinal Crypt Cell Apoptosis in the Murine Acute Graft-versus-Host Disease; E. Stuber, et al. 12. Apoptosis and Mucosal Lymphocytes: Defective Mucosal Lymphocyte Apoptosis is Associated with Inflammation; M. Boirivant, et al. 13. Regulation of Intestinal Epithelial Wound Healing; M.N. Goeke, D.K. Podolsky. 14. Myofibroblasts and Epithelial Repair in the Intestinal Mucosa; M.N. Goeke, D.K. Podolsky. 15. Etiopathogenesis 1999 - How to Put it All Together; C.O. Elson, et al. Section II: Clinical Approach and Treatment. 16. The Influence of 20th Century Biomedical Thought on the Origins of IBD Therapy; J.B. Kirsner. 17. Differentiation and Subgrouping of IBD: State of the Art; P. Rugeerts, et al. 18. Differentiation and Subgrouping of Crohn's Disease; G. Rocca, et al. 19. Do Subgroups of Crohn's Disease Matter for Future Patient Care? C. Gasche. 20. Treatment of Active, Severe and Refractory Ulcerative Colitis: State of the Art; S.B. Hanauer. 21. Treatment of active, severe and refractory ulcerative colitis: new therapeutic approaches, unpublished data; H. Herfarth. 22. Cyclosporin for Corticosteroid-Refractory Ulcerative Colitis. Refinement of Current Treatment Modalities; G.C. Actis, et al. 23. Two Decades of Restorative Proctocolectomy: Laudation or Requiem for the Ileoanal Pouch Procedure? C. Herfarth, et al. 24. Risk of Dysplasia in Long-Term Ileal Pouches or Pouches with Chronic Pouchitis; M. Thompson-Fawcett. 25. Improving the Long-Term Outcome of Surgery: The Future; R.S. McLeod. 26. Azathioprine Metabolism in IBD: Correlation with Efficacy and Toxicity; C. Cuffari. 27. Steriod Dependent and Refradctory Disease: State of the Art; D.H. Present. 28. Thalidomide Therapy: History, Pharmacology and Consideration as a Treatment for Crohn's Disease; E.D. Ehrenpreis, et al. 29. Maintenance of Remission in Ulcerative Colitis and Crohn's Disease; L.R. Sutherland. 30. Remission Maintenance in UC and CD: Unpublished Data; P. Gionchetti, et al. 31. Experimental Treatments in IBD &endash; Are Too Many and Do We Have the Right Targets? J. Schoelmerich. 32. Patient Education in Patients with Inflammatory Bowel Disease; N. Bregenzer, et al. 33. Supportive Care in Inflammatory Bowel Disease; E.J. Irvine. 34. How to Put it All together &endash; Visions for the Second Century; W.J. Sandborn. Index.