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Immune Infertility


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Table of Contents

Sperm Antigens.- Proteomics of Human Spermatozoa.- Methods of Analysis of Sperm Antigens Related to Fertility.- Sperm Surface Proteomics.- Sperm Functions Influenced by Immune Reactions.- Antisperm Antibodies (ASA).- The Immune Privilege of the Testis.- Immune Chemistry of ASA.- Sperm-Specific T Lymphocytes.- Site and Risk Factors of Antisperm Antibodies Production in the Male Population.- Biologic Substrates Containing ASA.- ASA in the Female.- Sperm-Immobilizing Antibody and Its Target Antigen (CD52).- The Clinical Impact of Sperm Antibodies.- Male Autoimmune Infertility.- Tests for Sperm Antibodies.- Impact on Fertility Outcome.- Sperm Antibodies and Assisted Reproduction.- Treatment of Immune Infertility.- Immune Contraception.- Immunization with Sperm Antigens to Induce Contraception.- Immunocontraception in Wildlife Animals.- Experience from Clinical Trials with Fertility Control Vaccines.


From the reviews: "The authors direct their work to clinicians, scientists, trainees in reproductive biology, obstetricians/gynecologists, and urologists. ! This highly specialized field is clearly depicted with the aid of graphs, tables, schematic diagrams, and exquisite photomicrographs. ! This is a unique, comprehensive, and cogent update of basic and therapeutic advances in the field of immunoinfertility." (Irvin H. Hirsch, Doody's Review Service, December, 2009)

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