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Contributors. Series Preface. Preface. Introduction. The Background to Autoimmunity, W.M. Williams, M.R. Ehrenstein, and D.A. Isenberg. Immunological Tolerance and its Implications for Autoimmunity, N.A. Mitchison. Peptide Blockade and Antigen-specific Modulation of Autoimmune Disease, D.C. Wraith. Monoclonal Antibody Therapy of Experimental Arthritis - Comparison with Cyclosparin A for Elucidating Cellular and Molecular Disease Mechanisms, M.E.J. Billingham. Anti-CD4 and Other Antibodies to Cell Surface Antigens for Therapy, F. Emmrich, H. Schulze-Koops, and G. Burmester. Are Imbalances in Cytokine Function of Importance in the Pathogenesis of Rheumatoid Arthritis?, M. Feldmann, F.M. Brennan, E.R. Abney, A. Hales, Y. Chernajovsky, P. Katsikis, A. Corcoran, C. Haworth, A. Cope, D. Gibbons, C.Q. Chu, M. Field, B. Deleuran, R.O. Williams, and R.N. Maini. Naturally Occuring Inhibitors of Cytokines, W.P. Arend and J.-M. Dayer. Soluble Immunopeptides in Inflammatory Arthritis, J.A. Symons and G.W. Duff. Inflammatory Reactions in Arthritis, H.-G. Fassbender. Connective Tissue Destruction in Rheumatoid Arthritis: Therapeutic Potential of Selective Metalloproteinase Inhibitors, B. Henderson and S. Blake. Lysosomal Cysteine Endopeptidases in the Degradation of Cartilage and Bone, D.J. Buttle. Glossary. Key to Illustrations. Index.