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Le sequencage de nombreux genomes eucaryotes indique que l'augmentation de la "biocomplexite" au cours de l'evolution n'est pas directement correlee a l'accroissement du nombre de genes. A cet egard, il semble de plus en plus clair que l'epigenetique est riche d'une information qui se superpose a celle du code genetique. L'information epigenetique est principalement vehiculee par des modifications de l'ADN et des histones. La modification majeure de l'ADN est la methylation de la cytosine. Quant aux histones, differentes modifications posttraductionnelles, regulees de facon dynamique et reversible, ont ete decrites, comme l'acetylation, la phosphorylation et la methylation. Dans cet ouvrage, nous nous sommes interesses a la demethylase PADI4 (peptidylarginine deiminase 4) qui convertit des residus arginines des histones en residus citrullines, ce qui a pour consequence d'entrainer une repression transcriptionnelle. Ce livre devrait aider a mieux cerner comment la premiere histone demethylase decrite, PADI4, verrouille l'expression genique."
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