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An Introduction to Medicinal Chemistry
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Table of Contents

1: Drugs and drug targets - an overview Part A Drug targets - structure and function 2: Protein structure and function 3: Enzymes: structure and function 4: Receptors: structure and function 5: Receptors and signal transduction 6: Nucleic acids: structure and function Part B Pharmacodynamics and pharmacokinetics 7: Enzymes as drug targets 8: Receptors as drug targets 9: Nucleic acids as drug targets 10: Miscellaneous drug targets 11: Pharmacokinetics and related topics Case study 1: Statins Part C Drug discovery, design, and development 12: Drug discovery: finding a lead 13: Drug design: optimizing target interactions 14: Drug design: optimizing access to the target 15: Getting the drug to market Case study 2: The design of ACE inhibitors Case study 3: Artemisinin and related antimalarial drugs Case study 4: The design of oxamniquine Part D Tools of the trade 16: Combinatorial synthesis 17: Computers in medicinal chemistry 18: Quantitative structure-activity relationships (QSAR) Case study 5: De novo design of a thymidylate synthase inhibitor Part E Selected topics in medicinal chemistry 19: Antibacterial agents 20: Antiviral agents 21: Anticancer agents 22: Cholinergics, anticholinergics, and anticholinesterases 23: Drugs acting on the adrenergic nervous system 24: Opioid analgesics 25: Antiulcer agents 26: Cardiovascular drugs Case study 6: Steroidal anti-inflammatory agents Case Study 7: Design of a novel antidepressant Case Study 8: The design and development of aliskiren Case Study 9: Factor Xa inhibitors Case Study 10: Reversible inhibitors of HCV NS3-4A protease Appendices

About the Author

Dr Graham Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he worked in the pharmaceutical industry as a research chemist and radiochemist on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants. His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of Paisley (now the University of the West of Scotland) in 1990, teaching medicinal chemistry and drug design.

Reviews

`It is by far the best book on the market for medicinal chemistry and drug discovery.' Professor Steven Bull, University of Bath `Summarizes the chemistry of medicinal agents in a manner that easily facilitates understanding of the core principles in the context of pharmacological drug action and clinical therapeutics.' Professor John Marriott, University of Birmingham

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