Table of Contents

1. Label-free biosensors: an introduction Brian T. Cunningham; 2. Experimental design Robert Karlsson; 3. Extracting affinity constants from biosensor binding responses Rebecca L. Rich and David G. Myszka; 4. Extracting kinetic rate constants from binding responses Rebecca L. Rich and David G. Myszka; 5. Sensor surfaces and receptor deposition Matthew A. Cooper; 6. Macromolecular interactions Francis Markey; 7. Interactions with membranes and membrane receptors Matthew A. Cooper; 8. Application of SPR technology to pharmaceutical relevant drug-receptor interactions Walter Huber; 9. High-throughput analysis of biomolecular interactions and cellular responses with resonant waveguide grating biosensors Ye Fang, Jack Fang, Elizabeth Tran, Xinying Xie, Michael Hallstrom, and Anthony G. Frutos; 10. ITC-derived binding constants Richard K. Brown, Michael Brandts, Ronan O'Brien, and William B. Peters; 11. Impedance technology applied to cell-based assays Ryan McGuinness and Ed Verdonk.

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A detailed technical review of label-free biosensor techniques with worked examples.

About the Author

Dr Matthew A. Cooper is Founder and Managing Director of Cambridge Medical Innovations and Co-Founder and Chief Scientific Officer of Akubio. Dr Cooper is consulted widely for biosensor, biotechnology, and pharmaceutical companies in the UK, Europe, and the United States. He is a review panel member for BBSRC, EPSRC, US NIH, US NIAID, and Science Foundation Ireland and a Fellow of the Royal Society of Medicine.