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The facts about Lyme disease, from epidemiology to treatment to control Lyme borreliosis, popularly known as Lyme disease, remains the most commonly reported tick-transmitted infection in North America and Europe. A growing body of scientific and clinical evidence has facilitated early diagnosis and effective treatment. Nonetheless, there are a number of misconceptions about this infectious disease that have given rise to unproven, potentially dangerous alternative therapies. In Lyme Borreliosis in Europe and North America, a team of authors whose expertise spans basic research, epidemiology, and clinical practice has compiled evidence-based information on Lyme borreliosis. Presents all the latest evidence needed to diagnose, treat, and prevent Lyme disease Lyme Borreliosis in Europe and North America begins with a review of the disease's epidemiology, the causative Borrelia genospecies, and tick vectors. It then explores pathogenesis, diagnosis, and treatment. Next, the book examines the role of serologic, culture, and molecular diagnostic methods. The book also features a chapter on prognosis, offering an evidence-based review of outcome studies, as well as practical advice to physicians to help them manage the challenging clinical scenario of chronic symptoms attributed to Borrelia infection. The final chapter is a guide to prevention strategies, including the management of tick bites. Examines similarities and differences in Europe and North America Because differences in Borrelia genospecies are responsible for differences in the clinical presentation of Lyme borreliosis between North America and Europe, this book provides descriptions of the disease as it presents on each continent. Most of the chapters have been cowritten by experts on each continent, in order to provide a balanced perspective that combines European and North American findings, practices, and experiences. Helps everyone better understand, treat, and control Lyme disease Lyme Borreliosis in Europe and North America is a comprehensive reference, ideal for clinicians, researchers, and public health officials who seek to treat and control Lyme borreliosis. It will help them better understand the facts and make sense of the misconceptions and myths that surround this infectious disease.
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Table of Contents

Preface vii Acknowledgment ix Contributors xi 1 THE EMERGENCE AND EPIDEMIOLOGY OF LYME BORRELIOSIS IN EUROPE AND NORTH AMERICA 1 Sunil K. Sood, Susan O'Connell, and Klaus Weber 2 THE SPIROCHETES AND VECTOR TICKS OF LYME BORRELIOSIS IN NATURE 37 Joseph Piesman and Pierre-Francois Humair 3 EARLY LYME BORRELIOSIS 53 Vijay K. Sikand and Robert R. Mullegger 4 LYME CARDITIS 81 Fadi A. Haddad and Sunil K. Sood 5 NERVOUS SYSTEM LYME BORRELIOSIS 93 John J. Halperin and Leif Dotevall 6 LYME ARTHRITIS 115 Frank Dressler, Patricia I. Irigoyen, Norman T. Ilowite, and Hans-Iko Huppertz 7 BORRELIAL LYMPHOCYTOMA AND ACRODERMATITIS CHRONICA ATROPHICANS 135 Mark B. Salzman and Robert R. Mullegger 8 LYME BORRELIOSIS COINFECTIONS WITH ANAPLASMA AND BABESIA 149 Paul M. Lantos and Peter J. Krause 9 THE ROLE OF CULTURE AND NUCLEIC ACID AMPLIFICATION IN DIAGNOSIS OF LYME BORRELIOSIS 159 Gary P. Wormser and Guiqing Wang 10 SERODIAGNOSIS OF LYME BORRELIOSIS 185 Barbara J. B. Johnson, Maria E. Aguero-Rosenfeld, and Bettina Wilske 11 PROGNOSIS OF PERSONS WITH LYME BORRELIOSIS 213 Eugene D. Shapiro and Sunil K. Sood 12 PREVENTION OF LYME BORRELIOSIS 225 Sunil K. Sood Index 245

About the Author

Dr. Sood practices Pediatric Infectious Disease Medicine and Pediatrics in Brooklyn, Manhasset, and New Hyde Park, New York. Dr. Sunil Sood graduated with an MD 32 years ago. He is a Professor of Clinical Pediatrics in the Department of Pediatrics at Albert Einstein College of Medicine; Chief of Pediatric Infectious Diseases, Firm Director, Pediatric Unit, Schneider Children's Hospital at North Shore, North Shore University Hospital.

Reviews

Finally, for those who consider themselves knowledgeableor who otherwise are interested in Lyme borreliosis, this book isan estimable presentation of what is known about Lyme borreliosisin Europe and North America. (Clinical InfectiousDiseases, 1 March 2013) "This is an excellent addition to the field, written by expertsand well researched and edited ... The book makes a valuablecontribution to the education of healthcare providers, from medicalstudents to infectious disease experts. I highly recommend it."(Doody's, 30 September 2011)

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