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Lymphedema: A Concise Compendium of Theory and Practice
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Table of Contents

Foreword: J. Lionel Villavicencio

Preface: BB Lee and Stanley Rockson

Section I - Introduction

1. General Overview

Byung-Boong Lee and Stanley G. Rockson

2 Etiology and Classification of Lymphatic Disorders

Stanley G. Rockson

3 Hereditary and Familial Lymphedemas

Peter Mortimer Section II - Embryology, Anatomy, & Histology

4. Lymphatic Vascular Development and Lymphangiogenesis

Stanley G. Rockson

5. Anatomy of the Lymphatic System and its Structural Disorders

Hiroo Suami Section III - Physiology, Pathophysiology and Lymphodynamics

6. General Overview

Stanley G. Rockson

7. Lymphodynamics

Stanley G. Rockson

8. Physiology- Lymph Flow

David C Zawieja

9. Biomechanics of the Lymphatic Circulation

James Moore

10. Pathology & Histochemistry

Waldemar Olszewski

11. The Cellular and Molecular Composition of Lymph

Laura Santambrogio Section IV - Clinical Diagnosis

12. General Overview

Stanley G. Rockson

13. Clinical Staging

Sandro Michelini 14. Combined Clinical and Laboratory (Lymphoscintigraphic) Staging Byung-Boong Lee, James Laredo, and Richard Neville 15. Diagnostic considerations in latent and early stage lymphedema Leigh Ward 16. Cutaneous manifestations of edema Peter Mortimer 17. Differential Diagnosis of Edema Stanley Rockson 18. Differential Diagnosis: Venous Edema Eri Fukuyama 19. Differential Diagnosis: Lipedema Gyozo Szolnoky Section V - Laboratory/Imaging Diagnosis 20. General Guidelines Andrzej Szuba 21. Radionuclide Lymphoscintigraphy Pierre Bourgeois 22. Duplex ultrasonography Attilio Cavezzi 23. Oil Contrast Lymphangiography J. Lionel Villavicencio 24. Fluorescent microlymphangiography Claudio Allegra 25. Near Infrared Fluorescent Lymphography Takumi Yamamoto 26. MR Lymphangiography NingFei Liu 27. Combined role of the lymphoscintigraphy, Xray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the management of lymphedematous disease Pierre Bourgeois 28. Alternative assessment & measurement tools Neil Piller Section VI - Physical and Medical Management 29. General Overview Stanley G. Rockson 30. Physiological principles of physiotherapy Ethel Foldi 31. Complex Decongestive Therapy Kristiane Gordon 32. Compression Therapy Hugo Partsch 33. Intermittent Pneumatic Compression Therapy Stanley G. Rockson 34. Other contemporary treatment modalities Neil Piller 35. Medical treatment options Stanley G. Rockson 36. Diagnosis and Managment of Infection in Lymphedema Waldemar Olszewski 37. The prospect for genetic and growth factor therapies Stanley G. Rockson 38. Compliance and Quality of Life Sheila Ridner 39. Lymphedema Healthcare Delivery Jane Armer Section VII - Practical issues in the Physiotherapeutic Approach to Lymphedema 40. Lower limb lymphedema Gyozo Szolnoky 41. Upper limb lymphedema Robert Damstra 42. Head, Face, & neck lymphedema Anne-Marie Vaillant-Newman and Stanley G. Rockson 43. Genital lymphedema Stephane Vigne Section VIII - Surgical treatment - Reconstructive Surgery 44. General Overview Peter Gloviczki 45. Principles of Patient Selection for Surgical Management Joseph Dayan 46. Lympho-venous bypass surgery Francesco Boccardo and Corradino Campisi 47. Lympho-lymphatic bypass surgery Ruediger Baumeister 48. Lymph node-to-venous bypass and other related reconstructive surgery Gurusamy Manokaran 49. Lymph nodes transplantation Dung Nguyen and Corinne Becker 50. Surgical Management of Lipedema Mark Smith 51. Controversies and Current Dilemmas in Reconstructive Surgery for Lymphedema Byung-Boong Lee, James Laredo, and Richard Neville 52. Future prospects in lymphatic reconstructive surgery David Chang Section IX - Surgical treatment: Excisional and Debulking Techniques < 53. Contemporary indications and controversies in excisional surgery Byung-Boong Lee, James Laredo, and Richard Neville 54. General Principles for debulking/excisional surgery Gurusamy Manokaran 55. Suction-Assisted Lipectomy for the Management of Lymphedema Hakan Brorson Section X - Congenital Vascular Malformation with Lymphatic Involvement 56. Primary lymphedema and Lymphatic Malformation Byung-Boong Lee, James Laredo and Richard Neville 57. Syndromic Lympedema and Complex Vascular Malformations with Lymphatic Involvement Francine Blei 58. An Atlas of Neonatal and Infantile Lymphedema Cristobal Miguel Papendieck and Miguel Amore Section XII - Management of Chyle Reflux and Effusions 59. Pathophysiology and Medical Management of Chylous Disorders Francine Blei 60. Surgical management of Chylous Reflux Steve Fishman 61. Endovascular Catheter-based Management of Chylous Effusions Max Itkin Section XII - Lymphatic Filariasis 62. Epidemiology LeAnn Fox 63. Etiology & Pathophysiology Thomas Nutman 64. Clinical Overview- Diagnosis & Management Gurusamy Manokaran Section XIV - Oncology and lymphedema 65. Breast cancer Sharon L. Kilbreath 66. Lower extremity cancers Mi-Joung Lee and Stanley G. Rockson 67. Radiation Complication Kathleen Horst Section - XV - Phlebolymphedema 68. Diagnosis and Management of Primary Phlebolymphedema James Laredo and Byung-Boong Lee 69. Diagnosis and Management of Secondary Phlebolymphedema Attilio Cavezzi 70. Management of phlebolymphedema ulcer Sergio Gianesini (and Erica Menegatti) Epilogue BB Lee & Stan Rockson

About the Author

Professor B.B. Lee began his career as a founding member of the transplant and vascular surgery program at Georgetown University, Washington, D.C., in 1979. He is now better known as a leading vascular surgeon in the field of veno-lymphatic disorders in the U.S. and a world authority on congenital vascular malformation and lymphedema. Prof. Lee, a disciple of the late David Hume of the Medical College of Virginia (Richmond, Virginia), has also made far-reaching contributions in the field of transplant surgery. During his tenure at Johns Hopkins University as clinical professor of surgery, he established a world-class living-related liver transplantation program in Seoul, Korea, as the founding professor and chairman of the Surgical Sciences Department at Samsung Medical Center and SungKyunKwan University. In recognition of his contributions to vascular surgery, Prof. Lee was named Distinguished Fellow by the Society for Vascular Surgery in the U.S. He has published over 800 original papers and abstracts in addition to more than four dozen book chapters, mainly in the field of vascular malformation and lymphedema. He has also given more than 500 lectures around the world. Prof. Lee has been serving on numerous national and international peer-reviewed journals as an editor as well as a reviewer specializing in the field of vascular malformation and lymphedema. He has played a critical role in introducing vascular malformation into the mainstream of vascular surgery. Consequently, Prof. Lee was invited by the Royal Society of Medicine and the American College of Phlebology Foundation to contribute as guest editor to a special issue of Phlebology on venous malformation in 2007. He was also invited by the American Venous Forum to write a chapter on AV malformation for the Handbook of Venous Disorders. Most notably, he was invited by the Society of Vascular Surgery/Journal of Vascular Surgery editorial board to write the vascular malformation chapter for Rutherford's Vascular Surgery, which remains the leading textbook for vascular surgeons around the world. Recently, both societies invited Prof. Lee back to write for, and update, their new editions. Prof. Lee has served as president or vice president on many national and international societies, including the IUA (International Union of Angiology) and the IUP (International Union of Phlebology). He has been elected to honorary as well as emeritus member status by numerous phlebology and lymphology societies throughout the world. For decades, he has led the IUP in addition to the IUA, boosting the image of both societies through his outstanding academic contributions. He has also successfully organized numerous world consensuses, including the consensuses on Primary Lymphedema and Venous Malformation for the IUP, in addition to the consensuses on AV malformation for the IUA. Until recently, Prof. Lee served on the ISVS (International Society of Vascular Surgery) as Vice President and also the American Specialty Board of Venous and Lymphatic Disease as a member of the Board of Directors, to promote this new specialty throughout the U.S. In 2011, Prof. Lee moved from Georgetown University to George Washington University, Washington, D.C., to provide worldwide services as the director of the Center for Vascular Malformation and Lymphedema. He also regularly contributes to the Uniformed Services University/Walter Reed Army Medical Center as Adjunct Professor and to Johns Hopkins University as Visiting Professor in addition to Georgetown University. Dr. Stanley Rockson is the Allan and Tina Neill Professor of Lymphatic Research and Medicine at Stanford University School of Medicine. After earning his medical degree from Duke University School of Medicine, Dr Rockson completed his internship and residency training in internal medicine at Brigham and Women's Hospital of Harvard Medical School, in Boston, Massachusetts, and fellowship training in the cardiac unit of Massachusetts General Hospital, Harvard Medical School. He is a fellow of the American College of Cardiology, Society of Vascular Medicine, American College of Angiology, and American College of Physicians, as well as a member of the International Society of Lymphology, American Society of Internal Medicine, and the Paul Dudley White Society, among others. As a principal investigator or co-investigator, he has been involved in numerous clinical trials researching various aspects of lymphatic disease, vascular biology and cardiovascular medicine. His basic research involves the investigation of disease pathogenesis and identification of biomarkers of lymphatic diseases, as well as research into molecular and pharmacologic therapeutics. As a Professor of Medicine, Dr. Rockson serves concurrently as the Stanford's Chief of Consultative Cardiology and the Director of the Stanford Center for Lymphatic and Venous Disorders. Dr Rockson is Editor-in-Chief of Lymphatic Research and Biology and sits on the editorial board of Angiology. Dr. Rockson works closely with National Institutes of Health, in an advisory capacity, to advance the agenda for lymphatic research. He has been a frequent invited lecturer at national and international meetings, congresses, and societies. He is the Founding Chair of the Scientific Advisory Board of the Lymphatic Research Foundation (now LE&RN) and has served as Chair of the inaugural Gordon Research Conference entitled 'Molecular Mechanisms in Lymphatic Function and Disease'. He is the co-author of Lymphedema: A Concise Compendium of Theory and Practice. Dr. Rockson has authored more than 150 scientific papers, reviews, book chapters and books devoted to various aspects of lymphatic biology and disease, vascular biology, and cardiovascular medicine.

Reviews

"This book is most suitable for clinicians and healthcare providers who encounter and participate in the care of patients with lymphedema. It is a valuable resource for trainees at many levels, particularly the sections about the history, pathogenesis, and clinical diagnosis of lymphedema. ... this book offers a much more thorough review of the biology and pathophysiology of these diseases. ... This updated edition provides new information regarding our understanding of lymphatic biology and current treatment approaches." (Katherine Hekman, Doody's Book Reviews, April, 2018)

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